- 4-Amino-1-butanol
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- $980.00 / 1KG
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2023-06-15
- CAS:13325-10-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1-10mt
- 4-Amino-1-butanol
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- $0.00 / 10kg
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2023-05-12
- CAS:13325-10-5
- Min. Order: 10kg
- Purity: 98%
- Supply Ability: ton grade
- 4-Amino-1-butanol
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- $100.00 / 25kg
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2023-01-31
- CAS:13325-10-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 50000KG/month
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| | 4-Amino-1-butanol Basic information |
| | 4-Amino-1-butanol Chemical Properties |
| Melting point | 16-18 °C (lit.) | | Boiling point | 206 °C (lit.) | | density | 0.967 g/mL at 25 °C (lit.) | | refractive index | n20/D ~1.462(lit.) | | Fp | 226 °F | | storage temp. | Store below +30°C. | | solubility | Acetonitrile (Slightly), Chloroform (Sparingly), Methanol (Slightly) | | form | Liquid | | pka | 15.10±0.10(Predicted) | | color | Clear colorless to slightly yellow | | Water Solubility | MISCIBLE | | Sensitive | Air Sensitive & Hygroscopic | | BRN | 1731411 | | Stability: | Unstable in Aqueous Solution | | CAS DataBase Reference | 13325-10-5(CAS DataBase Reference) | | NIST Chemistry Reference | NH2(CH2)4OH(13325-10-5) | | EPA Substance Registry System | 1-Butanol, 4-amino- (13325-10-5) |
| Hazard Codes | C | | Risk Statements | 34-22 | | Safety Statements | 26-36/37/39-45-25 | | RIDADR | UN 2735 8/PG 3 | | WGK Germany | 3 | | F | 34 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221980 |
| | 4-Amino-1-butanol Usage And Synthesis |
| Description | 4-Amino-1-butanol (4AB) is an important pharmaceutical intermediate compound and a precursor of biodegradable polymers for gene delivery. It can be used in organic synthesis and biological properties studies, among others. In addition, 4-Amino-1-butanol (4AB) has been shown to have a higher CO2 solubility than 2-amino-1-ethanol (MEA), which is potentially useful in solving problems related to flue gas purification[1-2]. | | Chemical Properties | Very light clear yellow liquid | | Uses | 4-Amino-1-butanol was used:
- As a linker in the synthesis of highly branched poly(β-amino esters)(HPAEs) for gene delivery.
- As a side chain to modulate antimicrobial and hemolytic activities of copolymers.
- In the total synthesis of (+)-fawcettimine,(+)-fawcettidine, and (?)-lycojapodine A.
| | Uses | 4-Amino-1-butanol is a useful intermediate in a variety of organic synthesis. It is mainly used in personal-care products, preparation of water soluble cationic flocculants and ion exchange resins as well as in the preparation of beta-lactam antibiotics. It is used for the production of efficient anionic emulsifiers, nonionic polyethylene emulsions, water treatment, metal treatment and absorption of carbon dioxide gas. It is used as a pigment dispersion aid and curing agent in selected textile -resins. | | Preparation | 4-Amino-1-butanol (4AB) can be prepared by microbiological methods. we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase (encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production. Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7?g/L of 4AB[1]. | | References | [1] CINDY PRICILIA SURYA PRABOWO. Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol[J]. Biotechnology and Bioengineering, 2020. DOI:10.1002/bit.27438.
[2] ZULKIFLI IDRIS . Equilibrium solubility of carbon dioxide in aqueous solutions of 3-amino-1-propanol, 4-amino-1-butanol and 5-amino-1-pentanol at low partial pressures[J]. Fluid Phase Equilibria, 2015. DOI:10.1016/j.fluid.2014.11.028.
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| | 4-Amino-1-butanol Preparation Products And Raw materials |
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