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| | Dopexamine hydrochloride Basic information |
| Product Name: | Dopexamine hydrochloride | | Synonyms: | 4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol dihydrochloride;dopexamine hydrochloride;1,2-Benzenediol, 4-(2-((6-((2-phenylethyl)amino)hexyl)amino)ethyl)-, dihydrochloride;Dopexamine HCl;DOPEXAMINE 2HCL;Dopexamine dihydrochloride CRS;4-(2-((6-(phenethylamino)hexyl)amino)ethyl)benzene-1,2-diol dihydrochloride;Beta Receptor,Adrenergic Receptor,Dopexamine,Inhibitor,Dopexamine hydrochloride,inhibit | | CAS: | 86484-91-5 | | MF: | C22H34Cl2N2O2 | | MW: | 429.42356 | | EINECS: | | | Product Categories: | APIs;Medicine intermediate;Amines;Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals | | Mol File: | 86484-91-5.mol |  |
| | Dopexamine hydrochloride Chemical Properties |
| Melting point | 213-215°C | | storage temp. | 2-8°C | | solubility | Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. | | color | White to Light Grey | | Stability: | Hygroscopic |
| | Dopexamine hydrochloride Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Uses | Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine hydrochloride has been used to improve myocardial and renal performance in patients suffering from low cardiac output states. | | Uses | Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine has been used to improve myocardial and renal performance in patients suffering from low cardiac output states. | | Brand name | Dopacard (Fisons). | | Clinical Use | Inotropic support in exacerbations of heart failure and
heart failure associated with cardiac surgery | | Drug interactions | Potentially hazardous interactions with other drugs
Anaesthetics: risk of ventricular arrhythmias with
isoflurane - avoid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Beta-blockers: risk of severe hypertension
Dopaminergics: avoid with rasagiline.
Sympathomimetics: effects of adrennoradrenaline possibly enhanced. | | Metabolism | Dopexamine is rapidly eliminated from blood with a halflife of approximately 6-7 minutes in healthy volunteers
and around 11 minutes in patients with cardiac failure.
Subsequent elimination of the metabolites is by urinary
and biliary excretion. |
| | Dopexamine hydrochloride Preparation Products And Raw materials |
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