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| | illudin S Basic information |
| Product Name: | illudin S | | Synonyms: | illudin S;(2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one;Illusin S;Lampterol;NSC-626369;Illudin;Illudine S;Lunamycin | | CAS: | 1149-99-1 | | MF: | C15H20O4 | | MW: | 264.32 | | EINECS: | | | Product Categories: | ADC | | Mol File: | 1149-99-1.mol |  |
| | illudin S Chemical Properties |
| Melting point | 124-126℃ | | Boiling point | 327.55°C (rough estimate) | | density | 1.0583 (rough estimate) | | refractive index | 1.4300 (estimate) | | storage temp. | -20°C, Inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | A light yellow solid | | pka | 12.50±0.70(Predicted) |
| | illudin S Usage And Synthesis |
| Description | Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents. | | Uses | Illudin S is a potent antitumor sesquiterpene. | | Uses | Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours. | | Definition | ChEBI: Illudin S is a sesquiterpenoid. |
| | illudin S Preparation Products And Raw materials |
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