| Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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| Tel: |
021-51320588 |
| Email: |
tauto@tautobiotech.com |
| Products Intro: |
Product Name:Nargenicin A1
CAS:70695-02-2
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:BVT-0204-M005
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| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:nargenicin A1
CAS:70695-02-2
Purity:98% (HPLC) Package:1mg;5mg
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| | nargenicin A1 Basic information |
| Product Name: | nargenicin A1 | | Synonyms: | Antibiotic CP-47444;CP-47444;Nodusmicin 9-(1H-pyrrole-2-carboxylate);Antibiotic 47444;NSC 355066;1H-Pyrrole-2-carboxylic acid, (1E,3R,4S,7S,8aS,10aR,11R,12R,13R,14R,14aS,14bS)-3,4,6,7,8,8a,10a,11,12,13,14,14a-dodecahydro-14-hydroxy-4-[(1R)-1-hydroxyethyl]-7-methoxy-1,3,13-trimethyl-6-oxo-11,14b-epoxy-14bH-naphth[2,1-e]oxecin-12-yl ester;Nargenicin A1
DISCONTINUED | | CAS: | 70695-02-2 | | MF: | C28H37NO8 | | MW: | 515.599 | | EINECS: | | | Product Categories: | | | Mol File: | 70695-02-2.mol |  |
| | nargenicin A1 Chemical Properties |
| Boiling point | 718.3±60.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C,protect from light | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | Off-white powder. | | pka | 14.03±0.20(Predicted) | | color | Off-white |
| | nargenicin A1 Usage And Synthesis |
| Description | Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS. Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells. In vivo, nargenicin (50 mg/kg, p.o.) reduces the number of colony-forming units (CFUs) in infected kidneys by 100,000-fold in a murine model of S. aureus infection. | | Uses | Nargenicin A1 is an antibiotic with a broad efficacy. | | storage | +4°C |
| | nargenicin A1 Preparation Products And Raw materials |
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