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| 1-(2-Methoxyphenyl)piperazine Basic information |
| 1-(2-Methoxyphenyl)piperazine Chemical Properties |
Melting point | 35-40 °C (lit.) | Boiling point | 130-133 °C/0.1 mmHg (lit.) | density | 1.095 g/mL at 25 °C (lit.) | refractive index | n20/D 1.575(lit.) | Fp | >230 °F | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | form | Liquid After Melting | pka | 8.98±0.10(Predicted) | color | Clear colorless to yellow | Water Solubility | Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water | Sensitive | Air Sensitive | BRN | 167888 | InChI | InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3 | InChIKey | VNZLQLYBRIOLFZ-UHFFFAOYSA-N | SMILES | N1(C2=CC=CC=C2OC)CCNCC1 | LogP | 1.67 | CAS DataBase Reference | 35386-24-4(CAS DataBase Reference) |
| 1-(2-Methoxyphenyl)piperazine Usage And Synthesis |
Chemical Properties | clear colorless to yellow liquid after melting | Uses | 1-(2-Methoxyphenyl)piperazine can be used:
- To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
- To prepare cyclic amine substituted Tr?ger′s base derivatives.
- To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.
| Uses | It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders. | Uses | A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP). | Definition | ChEBI: 1-(2-methoxyphenyl)piperazine is a member of piperazines. |
| 1-(2-Methoxyphenyl)piperazine Preparation Products And Raw materials |
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