Company Name: |
J & K SCIENTIFIC LTD.
|
Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:Tetrahydro 11-Deoxycorticosterone-d5 21-β-D-Glucuronide CAS:567-01-1 Package:10Mg,1Mg
|
Company Name: |
SynAsst Chemical.
|
Tel: |
021-60343070 |
Email: |
|
Products Intro: |
Product Name:3β,21-Dihydroxy-5α-pregnan-20-one CAS:567-01-1 Purity:96%Min Package:10g 100g 500g
|
Company Name: |
BOC Sciences
|
Tel: |
16314854226 |
Email: |
info@bocsci.com |
Products Intro: |
Product Name:Epiallopregnanolone CAS:567-01-1 Purity:95% Package:1G;10G;100G Remarks:Epiallopregnanolone, a metabolite of progesterone, is a novel derivative of the steroid Dehydroepiandrosterone (DHEA). Epiallopregnanolone is a 3β-isomer of allopregnanolone. Epiallopregnanolone is in
|
Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:Epiallopregnanolone CAS:567-01-1 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
|
| 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Basic information |
Product Name: | 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE | Synonyms: | 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE;5-A-pregnane-3-B-21-diol-20-one;5-ALPHA-PREGNAN-3-BETA, 21-DIOL-20-ONE;3-beta,5-alfa-Tetrahydrodeoxycorticosterone;3β,5α-Tetrahydrodeoxycorticosterone;1-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-7-hydroxy-9
a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]p
henanthren-1-yl]-2-hydroxyethan-1-one;"3β,5a-Tetrahydrodeoxycorticosterone";3β,5α-THDOC | CAS: | 567-01-1 | MF: | C21H34O3 | MW: | 334.49 | EINECS: | | Product Categories: | | Mol File: | 567-01-1.mol | |
| 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Chemical Properties |
storage temp. | Store at -20°C | solubility | ≤25mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide | form | crystalline solid |
| 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Usage And Synthesis |
Description | 3β,5α-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ; ), in mice (ED50s = 45.9 and >100 mg/kg, respectively). 3β,5α-THDOC has been found in the urine of women during the third trimester of pregnancy. | Uses | 3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons. | Uses | 3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown
that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons. | in vitro | epiallopregnanolone showed no effects on the gaba-mediated chloride flux through several types of recombinant gaba receptors. epiallopregnanolone inhibited the allopregnanolone-stimulated gaba-mediated chloride flux through gabaa receptors. epiallopregnanolone antagonized the inhibitory effects of allopregnanolone and ethanol on the population spike in the ca1 region of the hippocampal brain slices [1]. epiallopregnanolone selectively blocked the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[3]. | in vivo | in rats trained to discriminate either 0.8g/kg or 1.2 g/kg ethanol, 100 mg/kg epiallopregnanolone treatment decreased the maximum effect by 40% and 54% ethanol lever, respectively. epiallopregnanolone significantly decreased response rates when compared with control condition [1]. | references | [1] ginsburg b c, lamb r j. alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol[j]. alcoholism: clinical and experimental research, 2005, 29(9): 1621-1629. [2] macdonald r l, olsen r w. gabaa receptor channels[j]. annual review of neuroscience, 1994, 17(1): 569-602. [3] wang m, bckstrm t, landgren s. epiallopregnanolone selectively blocks the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[j]. acta physiologica scandinavica, 1999, 167(2): a5-a5. |
| 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Preparation Products And Raw materials |
|