ChemicalBook CAS DataBase List Ethyl 1-aminocyclopropanecarboxylate hydrochloride

Ethyl 1-aminocyclopropanecarboxylate hydrochloride synthesis

5synthesis methods

Product Name:Ethyl 1-aminocyclopropanecarboxylate hydrochloride
CAS Number:42303-42-4
Molecular formula:C6H12ClNO2
Molecular Weight:165.62

64-17-5 Synthesis

64-17-5
693 suppliers
$10.00/50g

22059-21-8 Synthesis

22059-21-8
423 suppliers
$14.00/1g

Ethyl 1-aminocyclopropanecarboxylate hydrochloride

42303-42-4
162 suppliers
$6.00/1g

Yield:42303-42-4 100%

Reaction Conditions:

with thionyl chloride at 0; for 2 h;Reflux;Green chemistry;

Steps:

3 Preparation of compound of formula III
The compound of the formula II (500.0 g, 4.95 mol) was added to ethanol (10 L) at room temperature, and thionyl chloride(883.4g, 7.43 mol) was added dropwise at 0 °C, and the reaction mixture was heated to reflux and stirred for 2 h. The solution was cooled to room temperature, concentrated, and washed three times with THF (1L×3) to give the compound of formula III, 819.8 g, yield 100%.

References:

Nanjing Yaoshi Technology Co., Ltd.;Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.;Shu Qingning;Wang Wei CN108863958, 2018, A Location in patent:Paragraph 0073; 0074; 0075; 0076

FullText

107259-05-2 Synthesis