ChemicalBook CAS DataBase List N-(4-CYANO-PHENYL)-GLYCINE

N-(4-CYANO-PHENYL)-GLYCINE synthesis

7synthesis methods

Product Name:N-(4-CYANO-PHENYL)-GLYCINE
CAS Number:42288-26-6
Molecular formula:C9H8N2O2
Molecular Weight:176.17

79-08-3 Synthesis

79-08-3
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$9.00/1g

873-74-5
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42288-26-6
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$14.00/1g

Yield:42288-26-6 88%

Reaction Conditions:

in water at 100 - 110; for 3 h;

Steps:

3
3.2.3 Preparation of [(4-cyanophenyl)amino]acetic acid (V) C₇H₆N₂ C2H3DPθ2 C₉H₈N₂O₂ MoI. Wt.: 1 18,14 MoI. Wt.: 138,95 MoI. Wt.: 176,17VIngredientsF: 90 g - 0.75 molG: 211.7 g - 1.5 molSodium bicarbonate: 35 g, 0.42 molThe starting substances F and G were mixed in 1250 ml of water and this suspension was inserted into a bath heated up to 100-110 ⁰C. After three hours of heating the reaction container was removed from the bath, cooled in the fridge and the separated substance was sucked off. The substance was dried in a vacuum drier at the temperature of 100 °C. Yield: Crude product: 122 g (92.8%), HPLC: 97%The crude product was purified by conversion to the sodium salt and re-acidification using an aqueous solution of sodium bicarbonate. The acid was released by means of diluted hydrochloric acid (1 :1). After sucking off and washing with water the product was dried in a vacuum drier (105 °C). Yield: Purified product: 115 g (88%), HPLC: 99.1%, water content: 0.13%; sulphate ash: 1.8%

References:

ZENTIVA, K.S. WO2009/111997, 2009, A1 Location in patent:Page/Page column 11

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