The synthetic methods of Dibucaine hydrochloride
Dibucaine hydrochloride blocks the generation and conduction of nerve impulses by reducing the permeability of neuronal cell membranes to sodium ions.
Oct 28，2025 API
The Application and Synthesis of 3-Acetylpyridine
3-Acetylpyridine is a pyridine derivative and it is primarily used as a raw material or intermediate for synthesizing various therapeutic drugs In the pharmaceutical field.
Oct 28，2025 Amides
Loperamide Hydrochloride: Therapeutic Antidiarrheal Use and Abuse Risks
Loperamide hydrochloride is an over-the-counter antidiarrheal , while high-dose abuse causes CNS issues and severe cardiotoxicity like QTc prolongation.
Oct 27，2025 API
Megestrol Acetate: Anticancer Mechanisms and CYP3A4 Induction
Megestrol acetate induces endometrial cancer cell senescence (PR-B/FOXO1/p21 axis), relieves CINV, but activates hPXR to induce CYP3A4.
Oct 27，2025 API
Isobutaneboronic Acid: Residual Solvent Determination & Derivatization
Isobutaneboronic acid uses DAN-derivatization to avoid GC column damage, enabling accurate residual solvent detection per ICH guidelines.
Oct 27，2025 API
Ethyl S-4-Chloro-3-Hydroxybutyrate: Bioreduction Synthesis & Production Enhancement
Ethyl S-4-chloro-3-hydroxybutyrate is synthesized via COBE bioreduction (high ee >99.9%) with cofactor recycling; adsorption systems boost production.
Oct 27，2025 Chemical Reagents
Corosolic Acid: Antidiabetic Effects & Structural Analogs
Corosolic acid boosts insulin sensitivity, modulates cancer pathways (NF-κB/PI3K/Akt), and has analogs with improved bioavailability.
Oct 27，2025 API
Taurodeoxycholic Acid Sodium Salt: Chaperoning Activity & In Vivo Toxicity
Taurodeoxycholic acid sodium salt (TDCA) acts as a chemical chaperone, has low systemic toxicity, but causes injection-site lesions at ≥20 mg/kg in rats.
Oct 27，2025 Chemical Materials
Applications of 3-Chloropropyltrimethoxysilane in Surface Modification of Materials
3-Chloropropyltrimethoxysilane enables surface functionalization, enhancing material stability, adsorption, membrane formation, and composite flame retardancy.
Oct 24，2025 Organic Chemistry
The use of Deslorelin in different animals
Deslorelin is a synthetic gonadotropin-releasing hormone (GnRH) agonist that is seven times more potent than GnRH. Its use in animals were reported here.
Oct 24，2025 Drugs