Understanding the Mechanism, Pharmacokinetics, and Side Effects of Prednisolone
Prednisolone binds to glucocorticoid receptors, with 70% bioavailability. Metabolism involves prednisone conversion. Overdose causes side effects.
Jan 9，2024 API
Zinc Pyrithione: A Promising Anti-Fungal Compound for Dermatologic Applications
Zinc Pyrithione has high skin permeability and exhibits anti-fungal activity against Malassezia yeast, commonly used in medicated shampoos for treating dandruff and seborrheic dermatitis.
Jan 9，2024 API
How is Ibrexafungerp synthesised?
Ibrexafungerp is synthesised in two steps by chemical reaction using enfumafungin as a raw material.
Jan 9，2024 Drugs
Agar-based edible films for food packaging applications
Agar can create edible films with gelling ability. Adding components like plasticizers and biopolymers improves flexibility and functional properties, expanding applications.
Jan 9，2024 API
A first-in-class potent 5-HT2A antagonist: Lumateperone
Lumateperone, also known as ITI-007, is a first-in-class potent 5-HT2A antagonist, postsynaptic D2 antagonist, and inhibitor of serotonin transport developed by Intra-Cellular Therapies under a licens
Jan 8，2024 API
The synthesis method of Lemborexant
Lemborexant is an orally administered dual orexin receptor (OXR) antagonist developed by Eisai for the treatment of adults with insomnia.
Jan 8，2024 API
How Lasmiditan works in treating migraine
Lasmiditan, or COL-144, is an orally bioavailable selective serotonin receptor agonist (SSRA) discovered by Eli Lilly and Company and licensed to CoLucid Pharmaceuticals before Eli Lilly acquired CoLu
Jan 8，2024 API
The introduction of Cenobamate (SQ 109)
Cenobamate is the latest approved antiepileptic drug in focal epilepsy, and its mode of action is thought to be mediated by blocking voltage-gated sodium channels and interacting with the GABAergic sy
Jan 8，2024 Biochemical Engineering
Candesartan cilexetil in cardiovascular disease
Candesartan cilexetil is an oral angiotensin II receptor blocker. Candesartan is approved by the FDA for the treatment of hypertension in adults.
Jan 8，2024 Drugs
How to synthesize Brexanolone？
Developed by Sage Therapeutics, brexanolone was approved by the USFDA as a first-in-class treatment for PPD in adult women.
Jan 8，2024 API