Fullerene C60: biological features, ROS generation and quenching and ROS-dependent biological effects
Fullerene C60 have antioxidant properties, generating singlet oxygen but limited ROS-quenching capacity, with promise in biomedical applications for their cytotoxic and cytoprotective effects.
Jan 12，2024 API
Exploring the Uses and Safety Considerations of Guanidine Carbonate
Guanidine carbonate has versatile applications due to its strong organic alkali properties, but requires careful handling due to potential health hazards and harm to aquatic life.
Jan 12，2024 API
Trifluoromethyl iodide: chemical and physical properties, pharmacokinetics and reproductive toxicity
Trifluoromethyl iodide is a stable, non-flammable gas with not significant reproductive toxicity, minimal metabolism and rapid equilibrium between air and blood.
Jan 12，2024 API
How to synthesise Nirmatrelvir on a large scale?
Nirmatrelvir is synthesised using saponification of bicycloproline ester.
Jan 12，2024 Drugs
Isotretinoin: Pharmacokinetics and Effectiveness
Isotretinoin can improve bioavailability when taken with food, eliminates via feces/urine, and low-dose regimens are effective. Combining with other treatments enhances outcomes.
Jan 12，2024 API
Zirconia (Zirconium dioxide): General properties; Commercial zirconia grades and Preparation
Pure zirconium dioxide (ZrO2), also called zirconia, is a dense material (5850 kg.m–3) that exhibits a high temperature of fusion (2710°C) and a good thermal conductivity (1.8 Wm–1K–1).
Jan 11，2024 API
Magnesite: General properties; Occurrence; Mining and Industrial applications
Magnesite (MgCO3) is like alumina, that is, it is considered either as an ore for magnesium metal production or as an industrial mineral.
Jan 11，2024 API
The four commercial grades of polyethylene
Polyethylene can be prepared in four commercial grades.
Jan 11，2024 Organic Chemistry
The synthesis method of Upadacitinib hemihydrate
Upadacitinib, a once-daily orally administered selective JAK1 inhibitor developed by AbbVie, was approved for the treatment of moderate to severe RA.
Jan 11，2024 Inhibitors
Seven steps to synthesize Peficitinib hydrobromide
Peficitinib is a Janus kinase (JAK)1, JAK2, JAK3, and tyrosine kinase (Tyk)2 (pan-JAK) inhibitor recently approved in Japan for the treatment of rheumatoid arthritis.
Jan 11，2024 API