Microbial Fermentation and Biosynthesis Pathways: L-Malic Acid Production in Multiple Industries
L-Malic acid is produced through microbial fermentation or chemical conversion, with glucose or fumaric acid as substrates. Enzyme expression and pH regulation are crucial for optimizing biosynthesis.
Jan 3，2024 API
An irreversible EGFR/HER2 dual tyrosine kinase inhibitor: Pyrotinib Maleate
Pyrotinib, an irreversible EGFR/HER2 dual tyrosine kinase inhibitor used for treating HER2-positive breast cancer, is primarily metabolized by cytochrome P450 (CYP)3A4 isozyme.
Jan 2，2024 Inhibitors
How to synthesize Lorlatinib?
Lorlatinib is an oral small molecule inhibitor of anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (ROS1) kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.
Jan 2，2024 Inhibitors
The Synthetic method of Larotrectinib (LOXO-101)
Larotrectinib (LOXO-101) is the first highly potent and selective small molecule ATP competitive inhibitor of all three TRK kinases (TRKA, TRKB, and TRKC) to enter clinical development.
Jan 2，2024 API
Properties and Applications of Silicone Oil
Silicone oils are constituted of a linear chain of siloxane repeating units (–Si–O) and a variety of side chains (radical side groups).
Jan 2，2024 API
Sodium carbonate: Applications and Security
Sodium carbonate is the disodium carbonate salt with an alkaline base. It is widely used in industry.
Jan 2，2024 API
Polyethylene glycol immunogenicity: anti-polyethylene glycol antibody
Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance, block anti
Jan 2，2024 API
The Biological function of Aviptadil
Aviptadil is a synthetic Vasoactive Intestinal Peptide (VIP) that has been studied in respiratory disease conditions.
Jan 2，2024 Biochemical Engineering
The Pharmacokinetics and uses of Teriparatide acetate
The anabolic drug teriparatide acetate has been introduced as a novel therapeutic agent for osteoporosis.
Jan 2，2024 Biochemical Engineering
Synthesis of Ripretinib
Ripretinib was synthesized by construction of a 1,6-naphtholide involving the junction of an α-aryl ester and appropriately functionalized 4-aminopyridine.
Jan 2，2024 Inhibitors