MDV-3100 (Enzalutamide)- Pharmacodynamic Properties
MDV3100, known as Enzalutamide, is a second-generation androgen receptor (AR) signaling inhibitor. It is able to inhibit binding of androgens to the AR, AR nuclear translocation, and the association o
Dec 13，2019 Inhibitors
Dabigatran etexilate (BIBR-1048)- Pharmacology
Dabigatran etexilate (Pradaxa, BIBR 1048, Boehringer Ingelheim) is the prodrug of dabigatran (originally known as BIBR 953), a potent, nonpeptidic small molecule.
Dec 13，2019 Inhibitors
Larotrectinib (LOXO-101)- Pharmacodynamics
Larotrectinib (VITRAKVIR) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo Oncology in collaboration with Bayer AG.
Dec 13，2019 Inhibitors
AZD3759- preclinical and clinical studies
AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue.
Dec 13，2019 Inhibitors
Neratinib- pharmacology
Neratinib is an oral pan HER inhibitor that irreversibly inhibits the tyrosine kinase activity of epidermal growth factor receptors, EGFR (or HER1), HER2, and HER4.
Dec 13，2019 Inhibitors
AP26113- Pharmacodynamics
Brigatinib (AP26113) is a tyrosine kinase inhibitor with in vitro activity against a number of kinases, including ALK, ROS1, insulin-like growth factor-1 receptor (IGF-1R), FLT-3, and also epidermal g
Dec 13，2019 Inhibitors
BIBW2992 Dimaleate - Pharmacodynamics
Afatinib dimaleate (Tovok; BIBW2992; Gilotrif) is a salt form of Afatinib. Afatinib is a second-generation, orally administered, irreversible inhibitor of the ErbB family of tyrosine kinases.
Dec 13，2019 Inhibitors
Lenvatinib - pharmacodynamics
Lenvatinib (LenvimaTM) is a multitargeted receptor kinase inhibitor that inhibits the kinase activities of vascular endothelial-derived growth factor receptors.
Dec 13，2019 Inhibitors
Antifungal performance of Terbinafine hydrochloride
Terbinafine hydrochloride is a synthetic allylamine antifungal with a broad spectrum and used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch[1].
Dec 12，2019 API
The use of pivaldehyde in organic synthesis
Pivaldehyde is an example of an aldehyde with the tertiary-butyl group (with 3 methyl groups), attached to the carbonyl (C=O) [1].
Dec 12，2019 Chemical Reagents