| Identification | Back Directory | [Name]
ganoderenic acid A | [CAS]
100665-40-5 | [Synonyms]
ganoderenic acid A
(20E)-7β,15α-Dihydroxy-3,11,23-trioxolanosta-8,20(22)-diene-26-oic acid
(20E)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanosta-8,20(22)-dien-26-oic acid
Lanosta-8,20(22)-dien-26-oicacid, 7,15-dihydroxy-3,11,23-trioxo-, (7b,15a,20E)-
Lanosta-8,20(22)-dien-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7β,15α,20E)- | [Molecular Formula]
C30H42O7 | [MDL Number]
MFCD07779161 | [MOL File]
100665-40-5.mol | [Molecular Weight]
514.65 |
| Chemical Properties | Back Directory | [Boiling point ]
700.3±60.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.65±0.23(Predicted) | [color ]
White to off-white | [InChIKey]
OVUOUFPIPZJGME-UHFFFAOYSA-N | [SMILES]
CC12C(CC(C(C)=CC(=O)CC(C)C(=O)O)C1(CC(=O)C1C3(CCC(=O)C(C)(C)C3CC(O)C2=1)C)C)O |
| Hazard Information | Back Directory | [Description]
Ganoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities.1,2,3 It is an inhibitor of β-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes).2 Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 μg/ml.3 | [Uses]
Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth. | [Definition]
ChEBI:Ganoderenic acid A is a triterpenoid. | [References]
[1] Y. KOMODA. Structures of New Terpenoid Constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae)[J]. Chemical & pharmaceutical bulletin, 1985, 14 1: 4829-4835. DOI: 10.1248/cpb.33.4829
[2] D H KIM. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.[J]. Biological & pharmaceutical bulletin, 1999, 22 2: 162-164. DOI: 10.1248/bpb.22.162
[3] SRI FATMAWATI Ryuichiro K Kuniyoshi Shimizu. Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.[J]. Planta medica, 2010, 76 15: 1691-1693. DOI: 10.1055/s-0030-1249782 |
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