| Identification | More | [Name]
3-Bromobenzophenone | [CAS]
1016-77-9 | [Synonyms]
3-BROMOBENZOPHENONE
SALOR-INT L169765-1EA
BromoBenzophenone,m-
3-Bromobenzoylbenzene
m-Bromobenzophenone
3-Bromophenylphenyl ketone
3-Bromophenylphenylmethanone | [EINECS(EC#)]
213-808-5 | [Molecular Formula]
C13H9BrO | [MDL Number]
MFCD00672015 | [Molecular Weight]
261.11 | [MOL File]
1016-77-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white to beige-yellowish or orange powder | [Melting point ]
74.5-77.5 °C(lit.)
| [Boiling point ]
347.5°C (rough estimate) | [density ]
1.4245 (rough estimate) | [refractive index ]
1.5130 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [InChI]
InChI=1S/C13H9BrO/c14-12-8-4-7-11(9-12)13(15)10-5-2-1-3-6-10/h1-9H | [InChIKey]
XNUMUNIJQMSNNN-UHFFFAOYSA-N | [SMILES]
C(C1=CC=CC(Br)=C1)(C1=CC=CC=C1)=O | [CAS DataBase Reference]
1016-77-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HS Code ]
29147000 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to beige-yellowish or orange powder | [Uses]
3-Bromobenzophenone reacts with diphenylmethane to yield the bromo-TPE intermediate mTPE-Br, which serves as a building block for tetraphenylethylene-based derivatives[2]. | [Synthesis]
3-Bromobenzophenone can be prepared by a palladium-catalyzed Suzuki reaction between bromobenzoyl chlorides and boronic acids, serving as a key synthetic intermediate for ketoprofen[1]. It is also obtained from the reaction of 1,3-dibromobenzene with benzoyl chloride[2]. Alternatively, Suzuki coupling of 3-bromobenzoyl chloride with phenylboronic acid affords 3-bromobenzophenone in 64% yield[1]. | [References]
[1]do Amaral e Silva, N. A., & de Luna Martins, D. (2023). Suzuki–Miyaura Cross-Coupling for the Synthesis of Key Intermediates of Ketoprofen and Bifonazole Analogues. 27th International Electronic Conference on Synthetic Organic Chemistry, 105. https://doi.org/10.3390/ecsoc-27-16068
[2]Huang, J., Sun, N., Dong, Y., Tang, R., Lu, P., Cai, P., Li, Q., Ma, D., Qin, J., & Li, Z. (2012). Similar or Totally Different: The Control of Conjugation Degree through Minor Structural Modifications, and Deep‐Blue Aggregation‐Induced Emission Luminogens for Non‐Doped OLEDs. Advanced Functional Materials, 23(18), 2329–2337. https://doi.org/10.1002/adfm.201202639
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Alfa Aesar
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http://chemicals.thermofisher.cn |
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Energy Chemical
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