| Identification | More | [Name]
N-(1-Methylethyl)-benzenemethanamine | [CAS]
102-97-6 | [Synonyms]
AURORA KA-7714
n-(1-methylethyl)-benzenemethanamine
N-BENZYLISOPROPYLAMINE
N-BENZYL-N-ISOPROPYLAMINE
N-ISOPROPYLBENZYLAMINE
Benzylamine, N-isopropyl-
Benzylisopropylamine
Isopropylbenzylamine
n-(1-methylethyl)-benzenemethanamin
N-ISOPROPYLBENZYLAMINE/N-BENZYLISOPROPYLAMINE
N-(b-Hydroxyethyl)pyrrolidine
N-Isopropylbenzenemethanamine
N-Isopropylphenylmethanamine | [EINECS(EC#)]
203-067-6 | [Molecular Formula]
C10H15N | [MDL Number]
MFCD00008863 | [Molecular Weight]
149.23 | [MOL File]
102-97-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2735 | [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29214980 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR VERY SLIGHTLY YELLOW TO YELLOW LIQUID | [Application]
N-Isopropylbenzylamine was used as ligand in the preparation and characterization of bis(cyclopentadienyl)magnesium. It was also used in the synthesis of N-benzylideneisopropylamine-N-oxide. | [Preparation]
N-Isopropylbenzylamine is an organic intermediate, which can be obtained by reduction of N-isopropylbenzamide or by reductive amination of benzylamine and acetone. | [General Description]
N-Isopropylbenzylamine forms amine adducts with magnesocene at ambient temperature in toluene. | [Cytotoxicity]
The toxicity of N-isopropylbenzylamine was evaluated in SH-SY5Y, PC12, and SN4741 cell lines. Cells were treated with 0.3–10 mM N-isopropylbenzylamine for 24 hours, and cell viability was measured using MTT assay. N-isopropylbenzylamine concentration-dependently reduced cell viability in these cells. The IC50 values of N-isopropylbenzylamine on cell viability were 3.47, 1.49, and 3.21 mM for SH-SY5Y cells, PC12 cells, and SN4741 cells, respectively. N-isopropylbenzylamine produced toxicity in cell lines that model neurons. Moreover, the activation of nNOS and the production of intracellular NO might be involved in N-isopropylbenzylamine-induced toxicity in SN4741 cells[1]. | [References]
[1] Peng Xu . “N-isopropylbenzylamine, a methamphetamine mimics, produces toxicity via increasing nitric oxide in vitro.” Toxicology 480 (2022): Article 153337. |
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