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10236-14-3

10236-14-3 Structure

10236-14-3 Structure
IdentificationMore
[Name]

TRIETHYL 4-PHOSPHONOCROTONATE
[CAS]

10236-14-3
[Synonyms]

4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER
TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE
TRIETHYL 4-PHOSPHONO-2-BUTENOATE
TRIETHYL 4-PHOSPHONOCROTONATE
TRIETHYL 4-PHOSPHONOCROTONATE, TECH., 90 %, MIXTURE OF ISOMERS
Triethyl 4-phosphonocrotonate, predominantly trans, 92%
triethyl 4-phosphonocrotonate, cis + trans
triethyl 4-phosphonocrotonate, mixture of isomers
triethyl trans-4-phosphono-2-butenoate
Triethyl 4-phosphonocrotonate, cis + trans, tech. 90%
Triethyl 4-phosphonocrotonate, 92%, predominantly trans
[Molecular Formula]

C10H19O5P
[MDL Number]

MFCD00009192
[Molecular Weight]

250.23
[MOL File]

10236-14-3.mol
Chemical PropertiesBack Directory
[Appearance]

CLEAR LIGHT YELLOW LIQUID
[Boiling point ]

135 °C0.4 mm Hg(lit.)
[density ]

1.128 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.455(lit.)
[Fp ]

>230 °F
[form ]

Liquid
[color ]

Clear light yellow
[CAS DataBase Reference]

10236-14-3(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
[WGK Germany ]

3
[HazardClass ]

IRRITANT
[HS Code ]

29319090
Hazard InformationBack Directory
[Chemical Properties]

CLEAR LIGHT YELLOW LIQUID
[Uses]

Reactant for:
  • Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
  • Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
  • Orally bioavailable GPR40 agonist synthesis
  • Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
  • Preaparation of mGlu4R agonists
  • Dearomatizing cyclization of nicotinyl-substituted esters and ketones
[Uses]

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
[reaction suitability]

reaction type: C-C Bond Formation
Spectrum DetailBack Directory
[Spectrum Detail]

TRIETHYL 4-PHOSPHONOCROTONATE(10236-14-3)1HNMR
TRIETHYL 4-PHOSPHONOCROTONATE(10236-14-3)IR
TRIETHYL 4-PHOSPHONOCROTONATE(10236-14-3)FT-IR
TRIETHYL 4-PHOSPHONOCROTONATE(10236-14-3)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Triethyl 4-phosphonocrotonate, predominantly trans, 92%(10236-14-3)
[Alfa Aesar]

Triethyl 4-phosphonocrotonate, cis + trans, 94%(10236-14-3)
[Sigma Aldrich]

10236-14-3(sigmaaldrich)
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