| Identification | Back Directory | [Name]
SHIONONE | [CAS]
10376-48-4 | [Synonyms]
Shionon
SHIONONE
Shionone ,98%
21-Shionen-3-one
18,19-Seco-D:A-friedolup-19-en-3-one
Shionone, 98%, from Aster tataricus L. f.
2(1H)-Chrysenone,hexadecahydro-1,4b,6a,8,10a,12a-
hexamethyl-8-(4-methyl-3-pentenyl)-,(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-
3β,5,8,17aβ-Tetramethyl-3-(4-methyl-3-pentenyl)-D-homo-5α-androstan-17-one
2(1H)-Chrysenone, hexadecahydro-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methyl-3-penten-1-yl)-, (1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-
(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methylpent-3-enyl)-1,3,4,4a,5,6,7,9,10,10b,11,12-dodecahydrochrysen-2-one | [Molecular Formula]
C30H50O | [MDL Number]
MFCD06799428 | [MOL File]
10376-48-4.mol | [Molecular Weight]
426.72 |
| Chemical Properties | Back Directory | [Melting point ]
161-162° | [alpha ]
D26.5 -56.1° (c = 1.07 in chloroform) | [Boiling point ]
485.6±14.0 °C(Predicted) | [density ]
0.941±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [color ]
White to off-white | [Optical Rotation]
-56.126.5 (c 1.07, CHCl3) | [LogP]
10.401 (est) |
| Questions And Answer | Back Directory | [Uses]
Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections. |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Aster tataricus. | [Definition]
ChEBI: A tetracyclic triterpenoid that is perhydrochrysene which is substituted by methyl groups at positions 1, 4bbeta, 6aalpha, 8beta, 10abeta and 12a positions, by a 4-methylpent-3-enyl group
t the 8alpha position, and with an oxo group at position 2. | [in vivo]
Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema[1]. | Animal Model: | ICR male mice[1] | | Dosage: | 80 mg/kg | | Administration: | Orally administration; 3 days; once daily | | Result: | Reduced the ear edema for 11.3% by use shionone. |
| [target]
ERK | IkB | NOS | IKK |
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