| Identification | More | [Name]
ASTRAGALIN | [CAS]
480-10-4 | [Synonyms]
ASTRAGALIN
KAEMPFEROL-3-GLUCOSIDE
KAEMPFEROL-3-O-BETA-D-GLUCOPYRANOSIDE
KAEMPFEROL-3-O-GLUCOSIDE
4h-1-benzopyran-4-one,3-(beta-d-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyp
astragaline
k5
kaempferol-3-beta-glucopyranoside
kaempferol-3-beta-monoglucoside
kaempferol-3-d-glucoside
Kaempferol-3-glucoside 97%
ASTRAGALIN hplc
KAEMPFEROL-3-O-GLUCOSIDE WITH HPLC
Kaempferol 3-β-glucopyranoside
Kaempferol 3-β-monoglucoside | [EINECS(EC#)]
232-268-1 | [Molecular Formula]
C21H20O11 | [MDL Number]
MFCD00075932 | [Molecular Weight]
448.38 | [MOL File]
480-10-4.mol |
| Questions And Answer | Back Directory | [Overview]
Astragalin is a chemical compound. It can be isolated from Phytolacca americana (the American pokeweed) or in the methanolic extract of fronds of the fern Phegopteris connectilis.t is also found in wine.
| [Preparation]
method for the enzymatic synthesis of ASTRAGALIN comprises the following steps:
1) Cloning, expressing, and purifying the key enzymes required for the synthesis of ASTRAGALIN, including glycogen phosphorylase GP, glucose pyrophosphorylase GalU, flavanone-3-hydroxylase F3H, flavanone synthase FLS1, and flavonoid 3-O-glucosyltransferase UGT78K2;
2) Muscle glycogen (Gn) synthesizes glucose-1-phosphate (G-1-P) under the action of GP;
3) G-1-P synthesizes uridine diphosphate glucose (UDPG) under the action of GalU;
4) Naringin (NRN) synthesizes dihydrokaempferol (DHK) under the action of F3H;
5) DHK synthesizes kaempferol (KMF) under the action of FLS1;
6) KMF and UDPG synthesize ASTRAGALIN under the action of UGT78K2. This invention involves fewer steps, milder operating conditions, fewer byproducts, higher yield, no pollution, and significantly reduced production costs. | [source]
Astragalin belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position. Astragalin exists as a solid, slightly soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, astragalin is primarily located in the cytoplasm. Astragalin can be converted into astragalin heptaacetate and 2''-acetylastragalin. Outside of the human body, astragalin can be found in a number of food items such as tamarind, american cranberry, chickpea, and bilberry. This makes astragalin a potential biomarker for the consumption of these food products.
|
| Chemical Properties | Back Directory | [Melting point ]
223-229°C | [Boiling point ]
823.2±65.0 °C(Predicted) | [density ]
1.79±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml | [form ]
neat | [pka]
6.20±0.40(Predicted) | [color ]
Yellow | [biological source]
mouse | [Detection Methods]
NMR,HPLC | [Cosmetics Ingredients Functions]
ANTIOXIDANT
SKIN CONDITIONING - MISCELLANEOUS | [InChIKey]
JPUKWEQWGBDDQB-QSOFNFLRSA-N | [SMILES]
O=C1C(=C(C2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C12)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O |&1:21,22,23,25,27,r| | [LogP]
1.950 (est) | [CAS DataBase Reference]
480-10-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow solid powder
| [Uses]
Astragaline is found in Erica multiflora leaf extract, which is used for mitigating high-?fat and high-?fructose diet (HFFD)?-?induced metabolic syndrome. | [Definition]
ChEBI: A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage. | [Biological Activity]
Similar kaempferol glycosides reduce food intake and corresponding weight gain in Wistar rats.The glucoside was not tested. | [in vivo]
Astragalin (25, 50, and 75 mg/kg; p.o.; once every two days; 25 d) reduces the tumor volumes, tumor weight and tumor formation rates and decreases expression of p-NFκB and p-iκκα in nude mouse model?with human colon cancer[1].
| Animal Model: | Male BALB/c nude mice (4-week-old) with HCT116 cells (s.c.)[1] | | Dosage: | 0 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg | | Administration: | Oral gavage; once every two days; for 25 days | | Result: | Resulted tumor inhibition rates of 17.43%, 34.89% (p?< 0.01), and 67.06% with 25 mg/kg, 50 mg/kg, 75 mg/kg dose administration.
Showed no effect on mouse weight. |
| [IC 50]
p65 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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