ChemicalBook--->CAS DataBase List--->10402-53-6

10402-53-6

10402-53-6 Structure

10402-53-6 Structure
IdentificationBack Directory
[Name]

Eprazinone dihydrochloride
[CAS]

10402-53-6
[Synonyms]

746CE
Eftapan
Mucitux
Resplen
Rozuplen
NSC 317935
Eprazinone 2HCl
Eprazinone diHCl
EPRAZINONE HYDROCHLORIDE
Eprazinone 2hydrochloride
Eprazinone dihydrochloride
3-(4-(2-Ethoxy-2-phenylethyl)
-2-methyl-1-phenylpropan-1-one dihydrochloride
3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiopheno...
1-(2-Benzoylpropyl)-4-(2-ethoxy-2-phenylethyl)piperazine dihydrochloride
3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-Methylpropiophenone dihydrochloride
3-[4-(beta-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride
Propiophenone, 3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methyl-, dihydrochloride (8CI)
3-[4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one dihydrochloride
1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-, dihydrochloride
1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-, hydrochloride (1:2)
Eprazinone DihydrochlorideQ: What is Eprazinone Dihydrochloride Q: What is the CAS Number of Eprazinone Dihydrochloride Q: What is the storage condition of Eprazinone Dihydrochloride Q: What are the applications of Eprazinone Dihydrochloride
[EINECS(EC#)]

233-872-8
[Molecular Formula]

C24H34Cl2N2O2
[MDL Number]

MFCD01695215
[MOL File]

10402-53-6.mol
[Molecular Weight]

453.44
Chemical PropertiesBack Directory
[Melting point ]

201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

Methanol (Slightly), Water (Slightly)
[form ]

Solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Originator]

Mucitux,Riom,France,1969
[Uses]

Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.
[Definition]

ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.
[Manufacturing Process]

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.
[Therapeutic Function]

Antitussive
Safety DataBack Directory
[Toxicity]

LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher)
Spectrum DetailBack Directory
[Spectrum Detail]

Eprazinone dihydrochloride(10402-53-6)1HNMR
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