ChemicalBook--->CAS DataBase List--->10402-90-1

10402-90-1

10402-90-1 Structure

10402-90-1 Structure
IdentificationMore
[Name]

Eprazinone
[CAS]

10402-90-1
[Synonyms]

1-(2-phenyl-2-ethoxy)ethyl-4-(2-benzoyl)propylpiperazine
EPRAZINONE
1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-
1-(2-phenyl-2-ethoxyethyl)-4-(2-benzyloxypropyl)piperazine
2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-propiophenon
3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propano ne
3-(4-(beta-ethoxyphenethyl)-1-piperazinyl)-2-methylpropiophenone
Eprazinone (base and/or unspecified salts)
β-[4-(β-Ethoxyphenethyl)-1-piperazinyl]-α-methylpropiophenone
[EINECS(EC#)]

233-873-3
[Molecular Formula]

C24H32N2O2
[MDL Number]

MFCD00866843
[Molecular Weight]

380.52
[MOL File]

10402-90-1.mol
Chemical PropertiesBack Directory
[Boiling point ]

508.13°C (rough estimate)
[density ]

1.0909 (rough estimate)
[refractive index ]

1.5500 (estimate)
[storage temp. ]

Sealed in dry,Room Temperature
[pka]

6.83±0.10(Predicted)
[CAS DataBase Reference]

10402-90-1(CAS DataBase Reference)
Questions And AnswerBack Directory
[Application]

Epradone is mainly used clinically for coughs caused by acute and chronic bronchitis, pneumonia, asthma, and tuberculosis.
Hazard InformationBack Directory
[Originator]

Mucitux,Riom,France,1969
[Definition]

ChEBI: A member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups.
[Manufacturing Process]

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.
[Therapeutic Function]

Antitussive
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