| Identification | More | [Name]
BROMPERIDOL | [CAS]
10457-90-6 | [Synonyms]
4-[4-(4-BROMOPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE
BROMPERIDOL
R 11333
4-(4-(4-bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanon
4-(4-(4-bromophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone
4-(4-(p-bromophenyl)-4-hydroxypiperidino)-4’-fluoro-butyrophenon
4-(4-(p-bromophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone
4-(4-(p-bromophenyl)-4-hydroxypiperidinol)-4’-fluorobutyrophenone
bromoperidol
Azurone
Azurene
Impromen
Tesoprel
R 11333, 4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
γ-[4-(p-Bromophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone | [EINECS(EC#)]
233-943-3 | [Molecular Formula]
C21H23BrFNO2 | [MDL Number]
MFCD00866670 | [Molecular Weight]
420.32 | [MOL File]
10457-90-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Tan Solid | [Melting point ]
156-158°C | [Boiling point ]
215.2°C (rough estimate) | [density ]
1.3109 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
H2O: insoluble
| [form ]
solid
| [pka]
8.6-8.7(at 25℃) | [color ]
white
| [Usage]
Bromine analog of Haloperidol. Antipsychotic | [CAS DataBase Reference]
10457-90-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [WGK Germany ]
3
| [RTECS ]
EU1180000
| [Toxicity]
mouse,LD50,intraperitoneal,156mg/kg (156mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985. |
| Hazard Information | Back Directory | [Chemical Properties]
Tan Solid | [Uses]
analgesic, antiinflammatory | [Uses]
Bromine analog of Haloperidol. Antipsychotic | [Definition]
ChEBI: Bromperidol is an aromatic ketone. | [Biological Activity]
Butyrophenone antipsychotic; D2 dopamine and 5-HT2A serotonin antagonist. | [in vivo]
Bromperidol antagonises stereotyped behaviour and agitation induced by apomorphine or amphetamine, and inhibits conditioned reactions and learned intracranial self-stimulation in rats[1].
Bromperidol antagonises apomorphine-induced emesis and inhibits the conditioned avoidance response in dogs[1]. | [IC 50]
D2 Receptor | [storage]
Store at -20°C |
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