| Identification | Back Directory | [Name]
ZK 112993 | [CAS]
105114-63-4 | [Synonyms]
ZK 112993
11β-(4-Acetylphenyl)-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one | [Molecular Formula]
C29H32O3 | [MDL Number]
MFCD32200351 | [MOL File]
105114-63-4.mol | [Molecular Weight]
428.563 |
| Hazard Information | Back Directory | [Uses]
ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1]. | [References]
[1] C A Sartorius, et al. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 5;268(13):9262-6. PMID:8387487
[2] Claudia Lanari, et al.? Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 May 3;19(3):R35-50. DOI:10.1530/ERC-11-0378 |
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