| Identification | Back Directory | [Name]
ZK 756326 | [CAS]
874911-96-3 | [Synonyms]
CS-2219
ZK 756326
ZK756326 2HCl
2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol
2-[2-[4-[(3-Phenoxyphenyl)methyl]piperazin-1-yl]-ethoxy]-ethanol
Ethanol, 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]-
2-(2-(4-(3-phenoxybenzyl)piperazin-1-yl)ethoxy)ethanoldihydrochloride
2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanoldihydrochloride | [Molecular Formula]
C21H28N2O3 | [MDL Number]
MFCD09038571 | [MOL File]
874911-96-3.mol | [Molecular Weight]
356.46 |
| Hazard Information | Back Directory | [Uses]
2-?[2-?[4-?[(3-?Phenoxyphenyl)?methyl]?-?1-?piperazinyl]?ethoxy]?-ethanol is a nonpeptide CCR8 chemokine receptor agonist that inhibits the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM (1). It is a useful compound to investigate the physiological role of CCR8 in HIV infection. | [Biological Activity]
Selective, non-peptide CCR8 chemokine receptor agonist (IC 50 values are 1.8 and 2.6 μ M for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α 2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. | [storage]
Desiccate at RT |
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| Company Name: |
Struchem Co., Ltd.
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| Telephone: |
0512-63009836 18994340901 |
| Website: |
http://www.beidapharma.com |
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