| Identification | Back Directory | [Name]
ZK118182 isopropyl ester | [CAS]
154927-31-8 | [Synonyms]
ZK118182 isopropyl ester
QLJUNFBXIBNQOL-LMJZMJOFSA-N
ZK118182 isopropyl ester Exclusive
propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate
Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI) | [Molecular Formula]
C23H37ClO5 | [MDL Number]
MFCD00929952 | [MOL File]
154927-31-8.mol | [Molecular Weight]
428.99 |
| Chemical Properties | Back Directory | [Boiling point ]
553.1±50.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | [pka]
14.22±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid. | [Uses]
ZK118182 Isopropyl ester is the isopropyl ester analog of ZK118182, a prostaglandin analog[1]. | [storage]
Store at -20°C | [References]
[1] Sharif N A, et al. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes[J]. Journal of Ocular Pharmacology & Therapeutics, 2004, 20(6): 489-508. |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
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Energy Chemical
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http://www.energy-chemical.com |
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Boao Pike
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www.biopike.cn |
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