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1780259-94-0

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1780259-94-0 Structure

1780259-94-0 Structure
IdentificationBack Directory
[Name]

ZK756326(dihydrochloride)
[CAS]

1780259-94-0
[Synonyms]

ZK756326(dihydrochloride)
ZK 756326 (hydrochloride)
[Molecular Formula]

C21H29ClN2O3
[MDL Number]

MFCD09038571
[MOL File]

1780259-94-0.mol
[Molecular Weight]

392.92
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

PBS (pH 7.2): 10 mg/ml
[form ]

A crystalline solid
[color ]

White to off-white
[InChI]

InChI=1S/C21H28N2O3.ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;/h1-8,17,24H,9-16,18H2;1H
[InChIKey]

GPPMZVONOXAYET-UHFFFAOYSA-N
[SMILES]

C(N1CCN(CCOCCO)CC1)C1C=CC=C(OC2C=CC=CC=2)C=1.Cl
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.
[IC 50]

CCR8: 1.8 μM (IC50, in U87 cells); 5-HT2B: 4.4 μM (IC50); 5-HT1A: 5.4 μM (IC50); 5-HT6: 5.9 μM (IC50); 5-HT5A: 16 μM (IC50); 5-HT2C: 34.8 μM (IC50); α2A: <20 μM (IC50)
[References]

[1] Haskell CA, et al. Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16. DOI:10.1124/mol.105.014779
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