| Identification | More | [Name]
Diethyl (2-oxopropyl)phosphonate | [CAS]
1067-71-6 | [Synonyms]
ACETYLPHOSPHONIC ACID DIETHYL ESTER
AURORA KA-1476
DIETHYL(2-OXOPROPYL)PHOSPHONATE
DIETHYL ACETYLPHOSPHONATE
(2-Oxo-propyl)-phosphonicaciddiethylester
Diethyl(2-oxopropyl)phosphonate, 97 %
Diethyl acetylmethylphosphonate, 97%
Diethyl 2-oxopropylphosphonate
Diethyl Acetyl Methyl Phosphonate | [EINECS(EC#)]
682-094-9 | [Molecular Formula]
C7H15O4P | [MDL Number]
MFCD00044728 | [Molecular Weight]
194.17 | [MOL File]
1067-71-6.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLORLESS TO LIGHT YELLOW LIQUID | [Boiling point ]
126 °C9 mm Hg(lit.) | [density ]
1.01 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.433(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Miscible with tetrahydrofuran, ether, dichloromethane and chloroform. | [form ]
Liquid | [color ]
Clear colorless to light yellow | [InChI]
InChI=1S/C7H15O4P/c1-4-10-12(9,11-5-2)6-7(3)8/h4-6H2,1-3H3 | [InChIKey]
RSAFKRSMGOSHRK-UHFFFAOYSA-N | [SMILES]
P(CC(=O)C)(=O)(OCC)OCC | [CAS DataBase Reference]
1067-71-6(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
The synthesis steps of Diethyl (2-oxopropyl)phosphonate are as follows: S1. Add 5 kg of triethyl phosphite and 2 kg of chloroacetone to a reaction vessel, reflux at 120°C for 7 hours, and distill off excess triethyl phosphite to obtain the phosphate salt; S2. Add the phosphate salt obtained in step S1 to the reaction vessel, dissolve it in 15 L of tetrahydrofuran, cool to 0°C, and add 1.3 kg of 60% sodium hydride in batches, stirring for 30 minutes to obtain Diethyl (2-oxopropyl)phosphonate. |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29319090 | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLORLESS TO LIGHT YELLOW LIQUID | [Uses]
Diethyl (2-Oxopropyl)phosphonate, is used in the preparation of enantipure acetoxyalkanephosphonates thru dynamic enzymic kinetic resolution alpha- and beta-hydroxalkanephosphonates. | [Synthesis Reference(s)]
Tetrahedron, 34, p. 649, 1978 DOI: 10.1016/0040-4020(78)88099-5
Tetrahedron Letters, 17, p. 2829, 1976 DOI: 10.1016/S0040-4039(01)85513-1 | [reaction suitability]
reaction type: C-C Bond Formation |
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