| Identification | More | [Name]
Isoprenaline hydrochloride | [CAS]
51-30-9 | [Synonyms]
1,[3',4'-DIHYDROXYPHENYL]-2-ISOPROPYLAMINOETHANOL HYDROCHLORIDE
3,4-DIHYDROXY-ALPHA-[(ISOPROPYLAMINO)METHYL]BENZYLALCOHOL HYDROCHLORIDE
4-[1-HYDROXY-2-[(1-METHYLETHYL)AMINO]ETHYL]-1,2-BENZENEDIOL HYDROCHLORIDE
ALUDRINE HYDROCHLORIDE
DL-3,4-DIHYDROXY-N-ISOPROPYLPHENYLETHANOL AMINE HCL
DL-ISOPROTERENOL HYDROCHLORIDE
ISOPRENALINE HCL
ISOPRENALINE HYDROCHLORIDE
ISOPROPYLARTERENOL HYDROCHLORIDE
(+/-)-ISOPROTERENOL HYDROCHLORIDE
ISOPROTERENOL HYDROCHLORIDE
N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE
TIMTEC-BB SBB003172
2-benzenediol,4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-hydrochloride
3,4-dihydroxy-alpha-((isopropylamino)methyl)-benzylalcohohydrochloride
alpha-(isopropylaminomethyl)-3,4-dihydroxybenzylalcoholhydrochloride
euspiran
isadrine
isoprenalinechloride
isopropylnorepinephrine-hydrochloride | [EINECS(EC#)]
200-089-8 | [Molecular Formula]
C11H18ClNO3 | [MDL Number]
MFCD00012603 | [Molecular Weight]
247.72 | [MOL File]
51-30-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
165-175 °C (dec.)(lit.)
| [Boiling point ]
192°C (rough estimate) | [density ]
1.2296 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. | [form ]
White solid | [color ]
White to Off-White | [Stability:]
Stable, but may be air and light sensitive. Incompatible with strong oxidizing agents. | [Water Solubility ]
Soluble | [BRN ]
3917363 | [InChI]
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H | [InChIKey]
IROWCYIEJAOFOW-UHFFFAOYSA-N | [SMILES]
C1(=CC=C(O)C(O)=C1)C(O)CNC(C)C.Cl | [CAS DataBase Reference]
51-30-9(CAS DataBase Reference) | [EPA Substance Registry System]
51-30-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H303-H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
DO1925000
| [F ]
3-8-10 | [HS Code ]
29225090 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 oral in rabbit: 3070mg/kg |
| Hazard Information | Back Directory | [General Description]
Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air. | [Reactivity Profile]
An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. | [Air & Water Reactions]
May be sensitive to exposure to air and light. . Water soluble. | [Health Hazard]
SYMPTOMS: Symptoms of exposure to this compound may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating. | [Fire Hazard]
Flash point data for this chemical are not available. ISOPROTERENOL HYDROCHLORIDE(51-30-9) is probably combustible. | [Description]
Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction[1]. | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator. | [Definition]
ChEBI: DL-Isoprenaline hydrochloride is a member of catechols. | [Brand name]
Isuprel (Hospira); Isuprel (Sanofi Aventis); Vapo-
ISO (Fisons). | [Biological Activity]
Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ . | [Biochem/physiol Actions]
β-adrenoceptor agonist; increases cytosolic cAMP. | [storage]
Store at RT | [References]
[1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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