| Identification | More | [Name]
(-)-ISOPROTERENOL HYDROCHLORIDE | [CAS]
5984-95-2 | [Synonyms]
(-)-ISOPROTERENOL HYDROCHLORIDE
L-(-)-ISOPROTERENOL HYDROCHLORIDE
(-)-N-ISOPROPYL-L-NORADRENALINE HYDROCHLORIDE
(R)-3,4-DIHYDROXY-ALPHA-(ISOPROPYLAMINOMETHYL)BENZYL ALCOHOL HYDROCHLORIDE
(r)-isoprenalinehydrochloride
(r)-isoproterenolhydrochloride
1,2-benzenediol,4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-,hydrochloride,
benzylalcohol,3,4-dihydroxy-alpha-((isopropylamino)methyl)-,hydrochloride,(
l-isoprenalinechloride
l-isoprenalinehydrochloride
isopropylnoradrenaline
isoprotemol
(-)-N-ISOPROPYL-L-NORADRENALIN HYDROCHLO RIDE
Off-whitecrystalsHCl
1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride (9CI)
1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride, (R)-
Benzyl alcohol, 3,4-dihydroxy-a-[(isopropylamino)methyl]-, hydrochloride, (-)-(8CI)
(-)-Isoprenaline hydrochloride, (-)-N-Isopropyl-L-noradrenaline hydrochloride, (R)-3,4-Dihydroxy-α-(isopropylaminomethyl)benzyl alcohol hydrochloride | [Molecular Formula]
C11H18ClNO3 | [MDL Number]
MFCD00064548 | [Molecular Weight]
247.72 | [MOL File]
5984-95-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
175 °C (dec.)(lit.)
| [storage temp. ]
−20°C
| [solubility ]
soluble (50 mg/ml: H2O) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
soluble (50 mg/ml: H2O) | [BRN ]
6077193 | [InChI]
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H | [InChIKey]
IROWCYIEJAOFOW-UHFFFAOYSA-N | [SMILES]
CC(C)NCC(O)C1C=CC(O)=C(O)C=1.[H]Cl | [CAS DataBase Reference]
5984-95-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DO1926000
| [F ]
10 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
(-)-Isoproterenol hydrochloride is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator. | [Biochem/physiol Actions]
Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate. | [in vivo]
(-)-Isoproterenol hydrochloride (85 mg/kg; s.c.; daily for two consecutive days) induces ventricular remodeling (VR) in rat[1]. | Animal Model: | 180-200 g, 6-7 weeks, Healthy male Sprague Dawley rats[1] | | Dosage: | 85 mg/kg | | Administration: | S.c.; daily for two consecutive days | | Result: | Decreased the systolic blood pressure (SBP) levels, increased LV weight index (LVWI) and heart weight index (HWI), the average cross section area markedly increased, significant increased in the levels of NT-proBNP in the myocardium. |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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