| Identification | More | [Name]
H-7 DIHYDROCHLORIDE | [CAS]
108930-17-2 | [Synonyms]
H-7
H-7 DIHYDROCHLORIDE
H-7 (hydrochloride)
H-7 dihydrochloride,98%
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl
(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
(-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT
5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline Hydrochloride
Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE
(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
(+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE | [Molecular Formula]
C14H19Cl2N3O2S | [MDL Number]
MFCD00036961 | [Molecular Weight]
364.29 | [MOL File]
108930-17-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
215-225 °C | [storage temp. ]
2-8°C
| [solubility ]
H2O: 20 mg/mL
| [form ]
Light yellow lyophilized solid | [color ]
White to Off-White | [Water Solubility ]
water: 20mg/mL | [Usage]
A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases | [BRN ]
5840763 | [InChI]
1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H | [InChIKey]
OARGPFMFRLLKPF-UHFFFAOYSA-N | [SMILES]
Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23 | [CAS DataBase Reference]
108930-17-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [F ]
10 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor. | [Uses]
A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases | [Definition]
ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride. | [General Description]
A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells. | [Biochem/physiol Actions]
Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively | [storage]
Store at -20°C |
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