| Identification | Back Directory | [Name]
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH | [CAS]
109770-29-8 | [Synonyms]
SP28
Fam-β-Amyloid
β-Amyloid (1-28)
BETA-AMYLOID (1-28)
AMyloid b-Protein (1-28)
AMYLOID BETA-PROTEIN (1-28)
AMYLOID, BETA- (1-28), HUMAN
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
[Gln11] -β- Amyloid (1 - 28)
Human β-amyloid peptide(1-28)
amyloid B-protein fragment 1-28
BETA-AMYLOID PEPTIDE [1-28], HUMAN
AMYLOID-BETA PROTEIN (1-28), HUMAN
ALZHEIMER'S DISEASE PROTEIN [1-28]
AMYLOID BETA-PROTEIN FRAGMENT 1-28
AlzheiMer's Disease b-Protein (SP28)
Amyloidβ-Protein(1-28),β-Amyloid(1-28)
B-AMYLOID PROTEIN (1-28) >97% SYNTHETIC
ALZHEIMER'S DISEASE BETA-PROTEIN (SP28)
BETA-AMYLOID (1-28), N-TERMINAL UNLABELED
Amyloid beta-Protein (1-28) trifluoroacetate salt
AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE
AMYLOID BETA-PROTEIN (HUMAN, 1-43) TRIFLUOROACETATE
AMyloid β-Protein (1-28)
AlzheiMer's Disease β-Protein (SP28)
ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH USP/EP/BP
L-Lysine, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl- | [Molecular Formula]
C145 H209 N41 O46 | [MDL Number]
MFCD00133074 | [MOL File]
109770-29-8.mol | [Molecular Weight]
3262.46 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
White lyophilized powder. | [Sequence]
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH |
| Hazard Information | Back Directory | [Uses]
β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients. | [in vivo]
β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu2+ interaction[1]. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of Ka10 7 M-1[2]. | [References]
[1] Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95(4):270-82. DOI:10.1016/s0162-0134(03)00128-4
[2] Syme CD, et al. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techni DOI:10.1074/jbc.M313572200
[3] Jing-Ming Shi, et al. Dissecting the behaviour of β-amyloid peptide variants during oligomerization and fibrillation. J Pept Sci. 2017 Nov;23(11):810-817. DOI:10.1002/psc.3028 |
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