| Identification | Back Directory | [Name]
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-OH | [CAS]
166090-74-0 | [Synonyms]
BAP 1-42
A-BETA(1-42)
BETA-AMYLOID (1-42)
BETA-AMYLOID (1-40), RAT
BETA-AMYLOID, SODIUM SALT
Rat amyloid-β peptide 1-42
AMYLOID BETA-PROTEIN (1-42)
BETA-AMYLOID, FRAGMENT 1-42
BETA-AMYLOID (1-42) PEPTIDE
BETA-AMYLOID (AA 1-42) PEPTIDE
Amyloid b-peptide (1-42) (rat)
AMYLOID B-PEPTIDE (1-40) (RAT)
Amyloid β-peptide (1-42) (rat)
BETA-AMYLOID PEPTIDE (1-40), RAT
BETA-AMYLOID PEPTIDE (1-42), RAT
Amyloid beta-peptide (1-42) (rat)
AMYLOID BETA-PROTEIN FRAGMENT 1-42
AMYLOID-BETA PROTEIN (1-42), HUMAN
AMyloid b-Protein (1-42) (Mouse, rat)
PREDOMINANT AMYLOID B-PROTEIN FRAGMENT
Glycopeptide (mouse amyloid A4 peptide)
Beta-Amyloid Peptide (1-42), mouse, rat
BETA-AMYLOID PEPTIDE (1-40), MOUSE, RAT
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
AMYLOID BETA-PROTEIN (1-42) (MOUSE, RAT)
AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT)
AMYLOID BETA-PROTEIN (1-42) HYDROCHLORIDE
BETA-AMYLOID (1-42), N-TERMINAL UNLABELED
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
PN: WO0069900 SEQID: 961 unclaimed protein
H-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH
767: PN: US20090175821 SEQID: 961 claimed protein
H2N-D-A-E-F-R-H-D-S-G-Y-F-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V-I-A-OH
H2N-D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V-I-A-OH
ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA
ASP-ALA-GLU-PHE-GLY-HIS-ASP-SER-GLY-PHE-GLU-VAL-ARG-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA
H-ASP-ALA-GLU-PHE-GLY-HIS-ASP-SER-GLY-PHE-GLU-VAL-ARG-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-OH
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-OH
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-OH USP/EP/BP
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-OH HYDROCHLORIDE | [Molecular Formula]
C203H311N55O60S | [MDL Number]
MFCD00163049 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [Sequence]
Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala |
| Hazard Information | Back Directory | [Uses]
Substrate Cleavage Assays (30-100 μg/ml) | [Biological Activity]
Amyloid beta-peptide (1-42) (rat) is a 42 amino acid polypeptide that is toxic to hippocampal slices and can be used in Alzheimer's disease research. | [in vivo]
β-Amyloid (1-42), (rat/mouse) can induce Alzheimer's disease[4].
Induction of Alzheimer's disease[4] Background
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder mainly characterized by the abnormal accumulation of β-amyloid (Aβ) peptide. The oligomeric form of the Aβ peptide as being the critical initiator of neurotoxicity in the AD pathogenesis[4].
Specific Modeling Methods
Rat: Wistar ? male ? adult, weighing 240-260 g
Administration: 1 μg/μL ? Hippocampal injection ? single dose
Note
(1) β-Amyloid (1-42) needs to be processed into oligomers before use.
(2) β-Amyloid (1-42) was injected bilaterally into the hippocampus of rat brain in a volume of 1.0 μL over a period of 0.1 μL/min using 1 μL Hamilton syringe.
Modeling Indicators Indicator changes: Decreased the gene expression level of α7-nAChR and increased the mRNA expression of NMDA receptor 2A, and -2B subunits.
Behavior: β-Amyloid (1-42) aggregates increased the retention time and altered the behavioral response in rats after 15 days of injection.
Correlated Product(s): β-Amyloid (1-42), (rat/mouse) TFA (HY-P1388A);
β-Amyloid (1-40) (rat) (HY-P1387);
β-Amyloid (1-40) TFA (HY-P0265A) Opposite Product(s): / | [target]
| [storage]
Store at -20°C |
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