| Identification | Back Directory | [Name]
beta-Amyloid (1-42) human | [CAS]
107761-42-2 | [Synonyms]
β-Amyloid-42
Soy Oligopeptides
Bate-Amyloid(1-42)
Soy Peptide Powder
β-Amyloid: 1-42,human
2-Amyloid(1-42) Human
(1-42) (human)
Bate-Amyloid（1-42）human
Beta-AMyloid(1-42)TB500
Amyloid-β (1-42) Peptide
AMyloid b-Protein (1-42)
Amyloid β-Peptide (1-42)
Amyloid β-Protein (1-42)
Amyloid-β (1-42) Peptide
beta-Amyloid (1-42) human
AB42, betaamyloid peptide
β-Amyloid (1-42), human TFA
AMyloid (1-42) huMan peptide
Β-AMYLOID PEPTIDE (1-42), RAT
Amyloidb-Peptide(1-42)(human) | [EINECS(EC#)]
761-142-2 | [Molecular Formula]
C203H311N55O60S1 | [MDL Number]
MFCD00163049 | [MOL File]
107761-42-2.mol | [Molecular Weight]
4514.04 |
| Chemical Properties | Back Directory | [Melting point ]
205 °C | [density ]
0.23 g/cm3 | [storage temp. ]
-20°C | [solubility ]
Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO. | [form ]
Lyophilized | [color ]
Lyophilized White | [Odor]
Odorless | [Sequence]
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH | [InChIKey]
XPESWQNHKICWDY-QYFPAAMGSA-N | [CAS DataBase Reference]
107761-42-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material. | [Uses]
Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer?s disease and neurodegeneration. | [Application]
Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human(107761-42-2) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.
| [General Description]
Amyloid β Protein(107761-42-2) is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3. | [Biochem/physiol Actions]
Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic. | [storage]
Store at -20°C | [References]
[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4. |
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| Company Name: |
Binhai gill polypeptide co. LTD Gold
|
| Telephone: |
021-61263389 13524856427 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList326362/0_EN.htm |
| Company Name: |
Fuan Bio Gold
|
| Telephone: |
15002819872 |
| Website: |
fuanbio.com |
|