| Identification | Back Directory | [Name]
H-ILE-ILE-GLY-LEU-MET-OH | [CAS]
149385-65-9 | [Synonyms]
IIGLM
Aβ31-35
β-Amyloid (31-35)
ILE-ILE-GLY-LEU-MET
β-Amyloid 31-35(TFA)
BETA-AMYLOID (31-35)
H-ILE-ILE-GLY-LEU-MET-OH
AMyloid b-Protein (31-35)
AMYLOID BETA-PROTEIN (31-35)
H-ILE-ILE-GLY-LEU-MET-OH USP/EP/BP
Amyloid β-Protein Fragment 31-35
amyloid B-protein fragment 31-35*acetate
Amyloid β-Protein (31-35)/β-Amyloid (31-35)
AMYLOID-BETA PROTEIN (31-35), HUMAN, MOUSE, RAT
Isoleucinyl-isoleucinyl-glycinyl-leucinyl-methionine
L-Methionine, L-isoleucyl-L-isoleucylglycyl-L-leucyl-
Amyloid β-Protein (31-35) Ile-Ile-Gly-Leu-Met | [Molecular Formula]
C25H47N5O6S | [MDL Number]
MFCD06659094 | [MOL File]
149385-65-9.mol | [Molecular Weight]
545.74 |
| Chemical Properties | Back Directory | [Boiling point ]
866.4±65.0 °C(Predicted) | [density ]
1.137±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.24±0.10(Predicted) | [color ]
White to off-white | [Sequence]
H-Ile-Ile-Gly-Leu-Met-OH |
| Hazard Information | Back Directory | [Uses]
β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity. | [References]
[1] Milton NG, et al. The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. Neurosci Lett. 2002 Apr 5;322(2):131-3. DOI:10.1016/s0304-3940(02)00081-2
[2] Misiti F, et al. Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int. 2006 Oct;49(5):525-32. DOI:10.1016/j.neuint.2006.03.014
[3] M Jesús Pérez de Vega, et al. Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2078-82. DOI:10.1016/j.bmcl.2008.01.092 |
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