| Identification | More | [Name]
Cetrimide | [CAS]
1119-97-7 | [Synonyms]
CETRIMIDE
MYRISTYLTRIMETHYLAMMONIUM BROMIDE
N,N,N-TRIMETHYL-1-TETRADECANAMINIUM BROMIDE
N-TETRADECYL-N,N,N-TRIMETHYLAMMONIUM BROMIDE
(N-TETRADECYL)TRIMETHYLAMMONIUM BROMIDE
TETRADECYLTRIMETHYLAMMONIUM BROMIDE
TRIMETHYLMYRISTYLAMMONIUM BROMIDE
TRIMETHYL-TETRADECYLAMMONIUM BROMIDE
TTAB
alkyl*trimethylammoniumbromide*(c14,5%c16)
alkyltrimethylammoniumbromide
alkyltrimethylammoniumbromide(c14,5%c16)
alkyltrimethylammoniumbromide(c14,5%c16)chemical
ammonium,trimethyltetradecyl-,bromide
morpant
mytab
n,n,n-trimethyl-1-tetradecanaminiubromide
N,N,N-Trimethyl-1-tetradecanaminumbromide
quaternium13
Tetradecanaminium,N,N,N-trimethyl-,bromide | [EINECS(EC#)]
214-291-9 | [Molecular Formula]
C17H38BrN | [MDL Number]
MFCD00011770 | [Molecular Weight]
336.39 | [MOL File]
1119-97-7.mol |
| Chemical Properties | Back Directory | [Definition]
Myristyltrimethylammonium bro-mide. | [Appearance]
white powder | [Melting point ]
245-250 °C(lit.)
| [bulk density]
600kg/m3 | [density ]
1.1328 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5260 (estimate) | [storage temp. ]
Store below +30°C. | [solubility ]
H2O: 10 % (w/v)
| [form ]
Fine Crystalline Powder | [color ]
White | [PH]
pH (50g/l, 25℃ : 4.0～6.0 | [Stability:]
Stable. Hygroscopic. Incompatible with strong oxidizing agents. | [Water Solubility ]
20 g/100 mL | [Sensitive ]
Hygroscopic | [λmax]
λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02 | [Detection Methods]
T,NMR | [Merck ]
14,6336 | [BRN ]
3633227 | [InChIKey]
CXRFDZFCGOPDTD-UHFFFAOYSA-M | [LogP]
2.2 at 20℃ | [CAS DataBase Reference]
1119-97-7(CAS DataBase Reference) | [EPA Substance Registry System]
1119-97-7(EPA Substance) |
| Questions And Answer | Back Directory | [Physical properties]
Cetrimide is a white fine powder crystal with a melting point of 245°C
to 250°C. A rough estimate of its density is 1.1328. It is soluble in
water with a solubility of 20 g/100 mL. |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3263 8/PG 2 | [WGK Germany ]
3 | [RTECS ]
BS5776000 | [F ]
3 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29239000 | [Toxicity]
LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl) |
| Hazard Information | Back Directory | [Description]
MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4 | [Chemical Properties]
white powder | [Uses]
Disinfectant; deodorant; laboratory reagent. | [General Description]
Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant. | [Purification Methods]
Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.] | [References]
1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425
2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78
3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010
4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609 |
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