| Identification | More | [Name]
Hexadecyl trimethyl ammonium bromide | [CAS]
57-09-0 | [Synonyms]
(1-HEXADECYL)TRIMETHYLAMMONIUM BROMIDE
CETAB
CETRAMIDE
CETRIMIDE
CETRIMIDE PER USP
CETRIMONIUM BROMIDE
CETYLTRIMETHYLAMMONIUM BROMIDE
CTAB
CTABR
HEXADECYLTRIMETHYLAMMONIUM BROMIDE
N-CETYL-N,N,N-TRIMETHYLAMMONIUM BROMIDE
N-HEXADECYL-N,N,N-TRIMETHYLAMMONIUM BROMIDE
N-HEXADECYLTRIMETHYLAMMONIUM BROMIDE
N,N,N-TRIMETHYLTETRADECYLAMMONIUM BROMIDE
PALMITYLTRIMETHYLAMMONIUM BROMIDE
TIMTEC-BB SBB008910
TRIMETHYLHEXADECYL-AMMONIUM BROMIDE
1-Hexadecanaminium,N,N,N-trimethyl-,bromide
acetoquatctab
ammonium,hexadecyltrimethyl-,bromide | [EINECS(EC#)]
200-311-3 | [Molecular Formula]
C19H42BrN | [MDL Number]
MFCD00011772 | [Molecular Weight]
364.45 | [MOL File]
57-09-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
248-251 °C(lit.)
| [bulk density]
390kg/m3 | [density ]
1.1107 (rough estimate) | [refractive index ]
1.5260 (estimate) | [Fp ]
244 °C | [storage temp. ]
Store at RT. | [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
white
| [Odor]
Odorless | [PH]
5.0-7.0 (25℃, 0.1M in H2O) | [PH Range]
5 - 7 | [Stability:]
Stable. Incompatible with strong oxidizing agents. Protect from moisture. | [Water Solubility ]
13 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [λmax]
λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.05 | [Detection Methods]
T,NMR | [Merck ]
14,2025 | [BRN ]
3598189 | [Cosmetics Ingredients Functions]
PRESERVATIVE
ANTISTATIC
SURFACTANT - EMULSIFYING
ANTIMICROBIAL | [InChI]
1S/C19H42N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H/q+1;/p-1 | [InChIKey]
LZZYPRNAOMGNLH-UHFFFAOYSA-M | [SMILES]
[Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C | [Uses]
cetrimonium bromide is a quaternary ammonium salt that can prevent the proliferation of bacteria, fungi, and yeast in cosmetic preparation, while also act as an emulsifying agent. | [CAS DataBase Reference]
57-09-0(CAS DataBase Reference) | [EPA Substance Registry System]
57-09-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R50:Very Toxic to aquatic organisms.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection .
S60:This material and/or its container must be disposed of as hazardous waste .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
3
| [RTECS ]
BQ7875000
| [F ]
3 | [TSCA ]
Yes | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29239000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Skin Irrit. 2
STOT RE 2 Oral
STOT SE 3 | [Toxicity]
LD50 in mice, rats (mg/kg): 32.0, 44.0 i.v. (Isomaa, Bjondahl) |
| Hazard Information | Back Directory | [Chemical Properties]
White powder. Soluble in water, alcohol,
and chloroform.
| [Definition]
ChEBI: The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide. | [General Description]
Hexadecyltrimethylammonium bromide is a titrant for the potentiometric titration of perchlorate with ionselective electrodes. | [Biochem/physiol Actions]
Hexadecyltrimethylammonium bromide also called cetyltrimethylammonium bromide (CTAB), is a cationic surfactant. CTAB is employed for extraction of DNA. CTAB method is efficient, cost and time effective for DNA extraction. CTAB is used as a shaping material and reducing agent for nanoparticle generation. | [Purification Methods]
Crystallise it from EtOH, EtOH/*benzene or from wet acetone after extracting twice with pet ether. Shake it with anhydrous diethyl ether, filter and dissolve it in a little hot MeOH. After cooling in the refrigerator, the precipitate is filtered off at room temperature and re-dissolved in MeOH. Anhydrous ether is added and, after warming to obtain a clear solution, it is cooled and the crystalline material is collected. [Dearden & Wooley J Phys Chem 91 2404 1987, Hakemi et al. J Am Chem Soc 91 120 1987, Beilstein 4 IV 819.] | [References]
[1] Liu, Tingting et al. “Hexadecyl trimethyl ammonium bromide assisted growth of NiCo2O4@reduced graphene oxide/ nickel foam nanoneedle arrays with enhanced performance for supercapacitor electrodes?.” RSC Advances 7 (2022): 4029–4041. |
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