ChemicalBook--->CAS DataBase List--->1148148-01-9

1148148-01-9

1148148-01-9 Structure

1148148-01-9 Structure
IdentificationBack Directory
[Name]

BrettPhosPalladacycle
[CAS]

1148148-01-9
[Synonyms]

BrettPhos precatalyst
BrettPhos Palladacycle
BrettPhos Pd G1 Methyl-t-Butyl Ether Adduct
(BrettPhos) palladium(II) phenethylamine chloride
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-amino
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoeth
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ii)
Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II),98%
Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine-(2-(2-aminoethyl)phenyl)palladium(II) chloride
Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-Minoethyl)phenyl]palladiuM(II),Min.98%[BrettPhosPalladacycle]
Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II), Min. 98% [BrettPhos Palladacycle]
[Molecular Formula]

C43H63ClNO2PPd
[MDL Number]

MFCD23843793
[MOL File]

1148148-01-9.mol
[Molecular Weight]

797.805
Chemical PropertiesBack Directory
[Melting point ]

198-204 °C
[form ]

Powder
[color ]

white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26
Questions And AnswerBack Directory
[Reaction]

  1. Catalyst for cross-coupling reactions using aryl mesylates with electron-deficient anilines.
  2. Catalyst for rapid C-N bond-forming processes at low catalyst loading.
  3. Cross-coupling of 3-Bromo-2-aminopyridine with primary amines.
Reactions of 1148148-01-9
Hazard InformationBack Directory
[Uses]

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst for:
  • C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
  • Amination reaction
  • N-arylation of aminophenols
[General Description]

BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to ?40 °C, and can be used in a variety of cross-coupling protocols.
[reaction suitability]

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings
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