ChemicalBook--->CAS DataBase List--->115966-68-2

115966-68-2

115966-68-2 Structure

115966-68-2 Structure
IdentificationBack Directory
[Name]

Histatin 5
[CAS]

115966-68-2
[Synonyms]

Human histatin 5
Peptide F-A (human parotid saliva)
Histatin 5 (synthetic human re-Hst5)
L-Tyrosine, L-α-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-
[Molecular Formula]

C133H195N51O33
[MDL Number]

MFCD00210682
[MOL File]

115966-68-2.mol
[Molecular Weight]

3036.29
Chemical PropertiesBack Directory
[density ]

1.57±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[Sequence]

Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr
Hazard InformationBack Directory
[Uses]

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
[storage]

Store at -20°C
[References]

[1] Gusman H, et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontaldisease. Infect Immun. 2001 Mar;69(3):1402-8. DOI:10.1128/IAI.69.3.1402-1408.2001
[2] Helmerhorst EJ, et al. The human salivary peptide histatin 5 exerts its antifungal activity through the formation ofreactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42. DOI:10.1073/pnas.141366998
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