ChemicalBook--->CAS DataBase List--->217099-14-4

217099-14-4

217099-14-4 Structure

217099-14-4 Structure
IdentificationBack Directory
[Name]

CYCLO(-ARG-GLY-ASP-D-TYR-LYS)
[CAS]

217099-14-4
[Synonyms]

CYCLO(-RGDYK)
cyclo (Arg-Gly-Asp-Tyr-Lys)
CYCLO(-ARG-GLY-ASP-D-TYR-LYS)
Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt
Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl)
[Molecular Formula]

C27H41N9O8
[MDL Number]

MFCD08459533
[MOL File]

217099-14-4.mol
[Molecular Weight]

619.67
Chemical PropertiesBack Directory
[density ]

1.52±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

4.01±0.10(Predicted)
[color ]

White to off-white
[Sequence]

Cyclo(Arg-Gly-Asp-{d-Tyr}-Lys)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319
[Precautionary statements ]

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard InformationBack Directory
[Uses]

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
[IC 50]

αvβ3: 20 nM (IC50)
[References]

[1] Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36. PMID:11216533
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