| Identification | More | [Name]
FLURAZEPAM DIHYDROCHLORIDE | [CAS]
1172-18-5 | [Synonyms]
7-CHLORO-1-(DIETHYLAMINO)ETHYL-5-(2-FLUOROPHENYL)-3H-1,4-BENZODIAZEPIN-2(1H)-ONE DIHYDROCHLORIDE
FLURAZEPAM DIHCL
FLURAZEPAM DIHYDROCHLORIDE
FLURAZEPAM HCL
FLURAZEPAM HYDROCHLORIDE
1,3-dihydro-l)dihydrochloride
2h-1,4-benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluoropheny
benozil
dalmadorm
dalmadormhydrochloride
dalmane
dalmate
dormodor
felison
id480
id480dihydrochloride
insumin
lunipax
nsc-78559
ro5-6901 | [EINECS(EC#)]
214-630-0 | [Molecular Formula]
C21H25Cl3FN3O | [MDL Number]
MFCD00058189 | [Molecular Weight]
460.8 | [MOL File]
1172-18-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R33:Danger of cumulative effects. | [Safety Statements ]
S1/2:Keep locked up and out of the reach of children .
S22:Do not breathe dust .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3249 | [WGK Germany ]
3
| [RTECS ]
DF0875000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2933910000 | [Toxicity]
LD50 in mice (mg/kg): 290 i.p.; 870 orally; 84 i.v. (Randall) |
| Hazard Information | Back Directory | [General Description]
Odorless off-white to yellow crystalline powder. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
Flash point data for this chemical are not available. FLURAZEPAM DIHYDROCHLORIDE is probably combustible. | [Originator]
Dalmane, Roche,US,1970 | [Uses]
Flurazepam is used as an sedative, hypnotic.
This is a controlled substance (depressant). | [Definition]
ChEBI: Flurazepam hydrochloride is a benzodiazepine. | [Manufacturing Process]
13 grams of 5-(2-fluorophenyl)-7-chloro-2,3-dihydro-1H-1,4benzodiazepinone-(2) were dissolved in 100 ml of N,N-dimethylformamide andtreated with 10.3 ml of a solution of sodium methoxide in methanol containing 54 mmol or 2.95 grams of sodium methoxide. The resulting solution was stirred at about 20°C for 1 hour and then cooled in an ice-salt mixture to 0°C. A solution of diethylamino-ethyl chloride was prepared by dissolving 13.8 grams of diethylamino-ethyl chloride hydrochloride in cold dilute sodium hydroxide solution and extracting the base four times with 50 ml of toluene each time. The toluene extracts were combined, dried over anhydrous sodium sulfate, filtered and added to the reaction mixture.
The mixture was allowed to stand for 70 hours and then concentrated to a small volume under reduced pressure. The residue was dissolved in 100 ml of methylene chloride, washed with 75 ml of water, three times with 50 ml of saturated brine solution each time and filtered over neutral alumina (grade 1). The filtrate was evaporated to dryness and the resulting colorless oil taken up in ether, which was then saturated with hydrogen chloride. The pale yellow precipitate was filtered off and recrystallized from methanol/ether yielding 1[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-7-chloro-2,3-dihydro-1H-1,4benzodiazepinone-(2) dihydrochloride as pale yellow rods melting at 190° to 220°C with decomposition, (from British Patent 1,040,548). | [Therapeutic Function]
Hypnotic |
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