| Identification | Back Directory | [Name]
TRIMETHYLAMINE N-OXIDE HYDROCHLORIDE | [CAS]
1184-78-7 | [Synonyms]
TMAO
Triox
trimethyloxamine
TRIMETHYLAMINOXIDE
Trimethylamine oxide
TRIMETHYLAMINE N-OXIDE
trimethyl-oxido-ammonium
Trimethylamine N-oxide,98%
TriMethylaMine N-oxide 98%
Trimethylamine N-oxide,TMANO
n,n-dimethyl-methanaminn-oxide
N,N-Dimethylmethanamine N-oxide
Trimethylamine N-Oxide Anhydrous
Methanamine,N,N-dimethyl-,N-oxide
TRIMETHYLAMINE OXIDE HYDROCHLORIDE
TRIMETHYLAMINE N-OXIDE HYDROCHLORIDE
Trimethylamine N-Oxide Anhydrous | [EINECS(EC#)]
214-675-6 | [Molecular Formula]
C3H9NO | [MDL Number]
MFCD00082441 | [MOL File]
1184-78-7.mol | [Molecular Weight]
75.11 |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
220-222 °C(lit.)
| [Boiling point ]
133.8°C (rough estimate) | [density ]
0.9301 (rough estimate) | [vapor pressure ]
23.5Pa at 20℃ | [FEMA ]
4245 | TRIMETHYLAMINE OXIDE | [refractive index ]
1.4698 (estimate) | [storage temp. ]
Hygroscopic, Room Temperature, under inert atmosphere | [solubility ]
Chloroform, DMSO, Methanol (Slightly) | [form ]
Solid | [pka]
4.65(at 25℃) | [color ]
Pale Yellow | [Odor]
odorless | [Water Solubility ]
793g/L at 24.5℃ | [JECFA Number]
1614 | [Merck ]
14,9711 | [Stability:]
Hygroscopic | [LogP]
-2.79 | [EPA Substance Registry System]
Methanamine, N,N-dimethyl-, N-oxide (1184-78-7) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Definition]
ChEBI: An N-oxide derived from triethylamine. | [Description]
Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine (Item No. 21489).1 It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver.1,2,3 Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice.1,4 Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis.1,2 Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.4 | [Uses]
Trimethylamine?N-oxide can be used:
- As a demetallation?and decarbonylation?reagent for organometallic compounds.
- To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
- To mediate the conversion of thiols to disulfides.
| [General Description]
Trimethylamine?N-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea. | [Flammability and Explosibility]
Notclassified |
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