| Identification | More | [Name]
SCOPARONE | [CAS]
120-08-1 | [Synonyms]
6,7-DIMETHOXY-CHROMEN-2-ONE
6,7-DIMETHOXYCOUMARIN
6,7-DIMETHYLESCULETIN
AKOS 236-43
DIMETHYLESCULETIN
ESCULETIN DIMETHYL ETHER
SCOPARONE
6,7-Dimethoxy-2H-1-benzopyran-2-one
6,7-dimethoxy-benzopyran-2-on
6,7-dimethoxybenzopyran-2-one
6,7-dimethoxy-coumari
6,7-Dimethoxycoumarine
aesculetindimethylether
escoparone
scoparon
6,7-dimethoxy-2-benzopyrone
SCOPARONE, 98% BY HPLC
SCOPARONE(RG)
DIMETHOXYCOUMARIN
6,7-DIMETHYLESCULETIN WITH HPLC | [EINECS(EC#)]
204-369-0 | [Molecular Formula]
C11H10O4 | [MDL Number]
MFCD00006871 | [Molecular Weight]
206.19 | [MOL File]
120-08-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
143-145 °C (lit.) | [Boiling point ]
265.04°C (rough estimate) | [density ]
1.0858 (rough estimate) | [refractive index ]
1.4389 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
>8.4mg/mL in DMSO | [form ]
Powder | [color ]
Light yellow to yellow | [Merck ]
13,8479 | [Cosmetics Ingredients Functions]
ANTIOXIDANT | [InChI]
InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3 | [InChIKey]
GUAFOGOEJLSQBT-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=CC(OC)=C(OC)C=C2C=C1 | [LogP]
1.331 (est) | [CAS DataBase Reference]
120-08-1(CAS DataBase Reference) | [NIST Chemistry Reference]
2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R36:Irritating to the eyes.
R22:Harmful if swallowed. | [Safety Statements ]
S27/28:After contact with skin, take off immediately all contaminated clothing and wash imediately with plenty of.... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2811 | [WGK Germany ]
3 | [RTECS ]
GN6550000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29322090 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2 | [Safety Profile]
Poison by ingestion and
intraperitoneal routes. Experimental
reproductive effects. An anthypertensive
agent. When heated to decomposition it
emits acrid smoke and irritating fumes. |
| Hazard Information | Back Directory | [Uses]
Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis. | [Definition]
ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin. | [Synthesis Reference(s)]
Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859 | [General Description]
6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported. |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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