| Identification | More | [Name]
METHYL 4-AMINO-6-INDOLECARBOXYLATE | [CAS]
121561-15-7 | [Synonyms]
4-AMINO-6-METHOXYCARBONYL INDOLE
4-AMino-6-Methylcarboxylateindole
Methyl 4-AMinoindole-6-carboxylate
METHYL 4-AMINO-6-INDOLECARBOXYLATE
Methyl 4-AMino-6-indolecarboxylate Hy
Methyl4-amino-1H-indole-6-carboxylate
4-AMINOINDOLE-6-CARBOXYLIC ACID METHYL ESTER
METHYL 4-AMINO-6-INDOLECARBOXYLATE USP/EP/BP
4-AMINO-6-INDOLE CARBOXYLIC ACID METHYL ESTER
Methyl 4-Amino-6-indolecarboxylate Hydrochloride
4-amino-6-indole carboxylic acid methyl ester ,95%
1H-Indole-6-carboxylic acid, 4-aMino-, Methyl ester
1H-Indole-6-carboxylicacid,4-amino-,methylester(9CI)
4-amino-1H-indole-6-carboxylic acid methyl ester hydrochloride | [Molecular Formula]
C10H10N2O2 | [MDL Number]
MFCD00461176 | [Molecular Weight]
190.2 | [MOL File]
121561-15-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
160-163 °C(Solv: benzene (71-43-2)) | [Boiling point ]
429.8±25.0 °C(Predicted) | [density ]
1.339±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
17.03±0.30(Predicted) | [Appearance]
Light brown to brown Solid | [CAS DataBase Reference]
121561-15-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
In the pharmaceutical field, methyl 4-amino-6-indolecarboxylate is mainly used as an organic synthesis intermediate to synthesize a variety of drug compounds, such as methyl 4-amino-6-indolecarboxylate hydrochloride, which is used in drug synthesis. | [Synthesis]
To a solution of methyl 4-[(E)-2-(dimethylamino)vinyl]-3,5-dinitrobenzoate (D200) (10 g, 34 mmol, 1 eq.) in methanol (250 ml) was added 10% palladium charcoal (50% wet, 1.0 g, 5% w/w). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was ground with ethyl acetate/isohexane mixed solvent to afford methyl 4-amino-1H-indole-6-carboxylate (D201) (5 g, 77% yield) as a dark pink solid. Mass spectrometry analysis showed [M+H]+ = 191.0 and retention time (RT) = 1.20 min. | [References]
[1] Tetrahedron Letters, 2007, vol. 48, # 45, p. 7990 - 7993
[2] Patent: WO2004/50619, 2004, A1. Location in patent: Page 57
[3] Patent: WO2005/58915, 2005, A1. Location in patent: Page/Page column 18 |
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| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
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