| Identification | More | [Name]
Xylometazoline hydrochloride | [CAS]
1218-35-5 | [Synonyms]
2-(4-TERT-BUTYL-2,6-DIMETHYLBENZYL)-2-IMIDAZOLINE HYDROCHLORIDE
XYLOMETAZOLINE HCL
XYLOMETAZOLINE HYDROCHLORIDE
XYLOMETAZOLIN HYDROCHLORIDE
2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazolinmonohydrochloride
2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1h-imidazol
otrivinehydrochloride
otrivinhydrochloride
XYLOMETAZOLINE HYDROCHLORIDE CRYSTALLINE
1H-Imidazole, 2-4-(1,1-dimethylethyl)-2,6-dimethylphenylmethyl-4,5-dihydro-, monohydrochloride
XYLOMETAZOLINEHYDROCHLORIDE,USP
XYLONETAZOLINEHCL
2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole hydrochloride
Xylometazoline hydrochloride, 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride | [EINECS(EC#)]
214-936-4 | [Molecular Formula]
C16H25ClN2 | [MDL Number]
MFCD00238707 | [Molecular Weight]
280.84 | [MOL File]
1218-35-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
NJ2390000
| [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29332900 | [Toxicity]
LD50 orl-rat: 230 mg/kg KSRNAM 5,555,71 |
| Hazard Information | Back Directory | [Chemical Properties]
Xylometazoline hydrochloride is white or almost white, crystalline powder.
| [Originator]
Otrivin,Geigy,US,1959 | [Uses]
anthelmintic | [Uses]
Xylometazoline hydrochloride is used as a nasal decongestant.
| [Manufacturing Process]
62 grams of para-tertiany-butyl-ortho,ortho'-dimethyl-phenyl-acetonitrile
[obtainable, for example, by the method of Buu-Hoi and P. Cagniant, Bulletin
de la Societe Chimique de France, volume 9, page 891 (1942)], 20.6 grams of
ethylenediamine of 96% purity and 1.55 cc of carbon disulfide are heated
together in a distillation flask with the exclusion of moisture for 48 hours on a
boiling water bath. Ammonia is evolved. Upon cooling the reaction product
solidifies and is then dissolved in benzene, the solution is filtered while hot
with the addition of animal charcoal and petroleum ether is added. The
mixture is filtered to remove the impurities that are first precipitated and by
the further addition of petroleum ether 2-(para-tertiary-butyl-ortho,ortho'-
dimethyl-phenyl-methyl)-imidazoline is caused to crystallize out.
The product melts at 131° to 133°C after being recrystallized from a mixture of benzene and petroleum ether. It can be converted into its hydrochloride as
follows:
189 grams of 2-(para-tertiary-butyl-ortho,ortho'-dimethyl-phenyl-methyl)-
imidazoline are dissolved in 400 cc of absolute ethanol, the solution is
rendered acid by the addition of 104 cc of an ethanolic solution of hydrochloric
acid of 30% strength, the mixture is filtered with the addition of animal
charcoal, and dry ethyl acetate and absolute ether are added until
crystallization sets in. After cooling the mixture, the salt is filtered off with
suction and crystallized several times from absolute ethanol with the use of
animal charcoal and the addition of dry mixture of ethyl acetate and ether.
The hydrochloride so obtained melts at 327° to 329°C (with decomposition). | [Brand name]
Neo-Synephrine II (Sterling Winthrop); Otrivin
Hydrochloride (Ciba-Geigy). | [Therapeutic Function]
Adrenergic (vasopressor) | [General Description]
Xylometazoline hydrochloride is a derivative of imidazole, and a representative of the class of α1 agonists. It is commonly used in nasal decongestants, which works on the principle of constricting the blood vessels in the mucous membranes. | [Biochem/physiol Actions]
α-adrenoceptor agonist; imidazoline binding site ligand. | [Safety Profile]
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl. | [storage]
Store at -20°C |
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