| Identification | More | [Name]
2'-Chloro-4',5'-difluoroacetophenone | [CAS]
121872-94-4 | [Synonyms]
2'-CHLORO-4',5'-DIFLUOROACETOPHENONE
2-CHLORO-4,5-DIFLUOROACETOPHENONE
2-CHLORO-4,5-DIFLUOROPHENYLACETOPHENONE
2'-chloro-4',5'-difluoroacetophenonedup 21889
2-CHLORO-4,5-DIFLUOROPHENYLACETONE
2'-Chloro-4',5'-difluoroacetophenone | [Molecular Formula]
C8H5ClF2O | [MDL Number]
MFCD00671761 | [Molecular Weight]
190.57 | [MOL File]
121872-94-4.mol |
| Questions And Answer | Back Directory | [Synthesis]
At a temperature of 20°C to 40°C, 23.6 g (0.3 mol) acetyl chloride was added to a mixture containing 29.7 g (0.2 mol) 1-chloro-3,4-difluorobenzene and 40.0 g (0.3 mol) aluminum chloride, and the mixture was then stirred at 120°C for 2 hours. While still very hot, the mixture was poured onto 250 g of ice, and the separated oil was extracted with chloroethane. The extract was neutralized and washed with water, and the solvent was distilled off under reduced pressure to obtain 31.2 g (yield: 82%) of 2'-chloro-4',5'-difluoroacetophenone, boiling point: 65℃-67℃/4-5 mmHg. |
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