| Identification | Back Directory | [Name]
(R)-N-BOC-alpha-Ethylalanine, 98% ee, 98% | [CAS]
123254-58-0 | [Synonyms]
Boc-D-Iva-OH
N-Boc-D-isovaline
Boc-alpha-Et-L-Ala-OH
(R)-N-Boc-a-Ethylalanine
Boc-a-Me-D-Gly(Ethyl)-OH
(R)-N-BOC-Α-ETHYLALANINE
Boc-α-Me-D-Gly(Ethyl)-OH
(R)-N-BOC-alpha-Ethylalanine
(R)-N-BOC-α-Ethylalanine, 98% ee
(Tert-Butoxy)Carbonyl D-IsoValine
Boc-(R)-2-aMino-2-Methylbutanoic acid
(R)-N-BOC-alpha-Ethylalanine, 98%, 98% ee
(R)-N-BOC-alpha-Ethylalanine, 98% ee, 98%
D-Isovaline, N-[(1,1-dimethylethoxy)carbonyl]-
(R)-2-(T-butyloxycarbonylamino)-2-methylbutanoic acid
(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-methylbutanoic acid | [Molecular Formula]
C10H19NO4 | [MOL File]
123254-58-0.mol | [Molecular Weight]
217 |
| Chemical Properties | Back Directory | [Boiling point ]
341.845±25.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.083±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
2-8°C | [form ]
Powder | [pka]
4.125±0.11(predicted) | [color ]
White to pale yellow | [Optical Rotation]
-11.05° (C=0.009957 g/100ml, CHCL3) |
| Hazard Information | Back Directory | [Synthesis]
(R)-2-Amino-2-methylbutyric acid (2.05 g, 17.50 mmol), triethylamine (7.01 mL, 50.20 mmol) and di-tert-butyl dicarbonate (5.70 g, 26.00 mmol) were sequentially added to the reaction flask under nitrogen protection. Subsequently, tetrahydrofuran (20 mL) was added as a solvent and the reaction mixture was heated to the appropriate temperature for the reaction. After completion of the reaction, the mixture was cooled to room temperature. Extraction was carried out with ethyl acetate (50 mL x 3), the organic phases were combined and dried with anhydrous Na2SO4. The solvent was removed by distillation under reduced pressure to give the crude product. Purification by column chromatography (eluent: dichloromethane/methanol (v/v)=10/1) afforded 3.60 g of the colorless oily target product (R)-2-((tert-butoxycarbonyl)amino)-2-methylbutyric acid in 97.0% yield. | [References]
[1] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0471; 0472; 0473 |
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