| Identification | Back Directory | [Name]
Erythromycin ethylsuccinate | [CAS]
1264-62-6 | [Synonyms]
Esinol
Evesin
Refkas
Anamycin
Arpimycin
E-Mycin e
Eryliquid
Sigapedil
Monomycin
Wyamycin E
Erythro ES
erythroped
Durapaediat
Erythro-Holz
Paediathrocin
Erythromycin ethyl s
erythrocinethylsuccinate
ErythroMycin ethyl succina
ERYTHROMYCIN ETHYLSUCCINATE
ERYTHROMYCIN ETHLY SUCCINATE.
ERYTHROMYCINETHYLSUCCINATE,USP
ErythroMycin Ethylsuccinate API
ERYTHROMYCIN ETHYISUCCINATE USP
erythromycin,mono(ethylsuccinate)
ERYTHROMYCIN 2'-(ETHYL SUCCINATE)
Erythromycin ethyl succinate (6CI)
ERYTHROMYCIN 2'-(ETHYL BUTANEDIOATE)
Erythromycin Ethylsuccinate (200 mg)
Oxacyclotetradecane, erythromycin deriv.
erythromycin,mono(ethylsuccinate)(ester)
Erythromycin, 2'-(ethyl succinate) (7CI)
Succinic acid, monoester with erythromycin
ERYTHROMYCIN ETHYLSUCCINATE EPE(CRM STANDARD)
ERYTHROMYCIN ETHYLSUCCINATE USP(CRM STANDARD)
Erythromycin 2''-[3-(ethoxycarbonyl)propionate]
Erythromycin, mono(ethyl succinate) (ester) (8CI)
succinicacid,monoethylester,monoesterwitherythromycin
Succinic acid, ethyl ester, monoester with erythromycin (8CI)
Ethyl [(2R,3S,4R,6S)-4-dimethylamino-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradec-6-yl]oxy]-6-methyl-oxan-3-yl] butanedioate | [EINECS(EC#)]
215-033-8 | [Molecular Formula]
C43H75NO16 | [MDL Number]
MFCD00084692 | [MOL File]
1264-62-6.mol | [Molecular Weight]
862.05 |
| Chemical Properties | Back Directory | [Melting point ]
219-224 C | [Boiling point ]
778.19°C (rough estimate) | [density ]
1.1417 (rough estimate) | [refractive index ]
1.5280 (estimate) | [Fp ]
>110°(230°F) | [storage temp. ]
2-8°C | [solubility ]
ethanol: soluble50mg/mL | [form ]
solid | [pka]
13.09±0.70(Predicted) | [color ]
white | [Water Solubility ]
Freely soluble in organic solvents, practically insoluble in water | [Stability:]
Hygroscopic | [Major Application]
pharmaceutical
pharmaceutical small molecule | [InChIKey]
NSYZCCDSJNWWJL-UHFFFAOYSA-N | [SMILES]
C1(OC(=O)CCC(OCC)=O)C(N(C)C)CC(C)OC1OC1C(CC(C(C(C(O)C(O)(C)C(CC)OC(=O)C(C)C(OC2OC(C)C(O)C(C)(OC)C2)C1C)C)=O)C)(O)C | [CAS DataBase Reference]
1264-62-6 |
| Hazard Information | Back Directory | [Chemical Properties]
crystals | [Uses]
antibacterial | [Brand name]
E-Mycin (Pharmacia & Upjohn); E.E.S.
(Abbott); Eryped (Abbott); Pediamycin (Ross); Wyamycin
(Wyeth). | [Application]
Erythromycin Ethylsuccinate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][2][3] by various chromatography techniques. | [Definition]
ChEBI: Erythromycin ethylsuccinate is a erythromycin derivative that is erythromycin A in which the hydroxy group at position 3R is substituted by a (4-ethoxy-4-oxobutanoyl)oxy group. It is used for the treatment of a wide variety of bacterial infections. It is a succinate ester, a cyclic ketone, an erythromycin derivative and an ethyl ester. It is functionally related to an erythromycin A. | [General Description]
Erythromycin ethylsuccinate (EES, Pediamycin, EryPed) isthe ethylsuccinate mixed ester of erythromycin in which the2＇-hydroxyl group of the desosamine is esterified. It isabsorbed as the ester and hydrolyzed slowly in the body toform erythromycin. It is somewhat acid labile, and itsabsorption is enhanced by the presence of food. The ester isinsoluble in water but soluble in alcohol and ether. | [storage]
Store at -20°C | [References]
[1] FAHIMEH KAMAREI . Development of a stability-indicating high performance liquid chromatography method for assay of erythromycin ethylsuccinate in powder for oral suspension dosage form[J]. Arabian Journal of Chemistry, 2014, 7 6: Pages 1079-1085. DOI:10.1016/j.arabjc.2011.01.004.
[2] B. LIAWRUANGRATH S. L. High performance thin layer chromatographic determination of erythromycin in pharmaceutical preparations[J]. Chromatographia, 2001, 54 5-6: 405-408. DOI:10.1007/BF02492693.
[3] JACQUELINE WARDROP . Determination of Erythromycin and Related Substances in Enteric‐Coated Tablet Formulations by Reversed‐Phase Liquid Chromatography[J]. Journal of pharmaceutical sciences, 2000, 89 9: Pages 1097-1105. DOI:10.1002/1520-6017(200009)89:9<1097::AID-JPS1>3.0.CO;2-D. |
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Spectrum Chemical Manufacturing Corp.
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