| Identification | Back Directory | [Name]
alpha, oMega-DisucciniMidyl hexaethylene glycol | [CAS]
1334170-02-3 | [Synonyms]
NHS-PEG6-NHS
Bis-PEG7-NHS ester
α,ω-disuccinimidyl hexaethylene glycol
alpha, oMega-DisucciniMidyl hexaethylene glycol
4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid, 1,25-bis(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C26H40N2O15 | [MDL Number]
MFCD18916987 | [MOL File]
1334170-02-3.mol | [Molecular Weight]
620.6 |
| Hazard Information | Back Directory | [Description]
Bis-PEG7-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [Biological Activity]
Bis-PEG7-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [target]
| Cleavable | PEGs | Alkyl/ether | | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Mahendra Persaud Deonarai, et al. Biological materials and uses thereof. WO2016046574A1 |
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