| Identification | Back Directory | [Name]
Bis-Mal-Lysine-PEG4-TFP ester | [CAS]
1426164-53-5 | [Synonyms]
Bis-Mal-Lysine-PEG4-TFP ester
4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, 2,3,5,6-tetrafluorophenyl ester, (18S)- | [Molecular Formula]
C37H45F4N5O13 | [MDL Number]
MFCD28385461 | [MOL File]
1426164-53-5.mol | [Molecular Weight]
843.77 |
| Chemical Properties | Back Directory | [Boiling point ]
1012.1±65.0 °C(Predicted) | [density ]
1.364±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [form ]
Solid | [pka]
14.12±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bis-Mal-Lysine-PEG4-TFP ester contains two malimide end groups which can react with thiol groups from pH 6.5 to 7.5 to form thiolester bonds. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG linker increases the compound's water solubility in aqueous environments. | [Uses]
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Nextpeptide Inc
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+86-0571-81612335 +8613336028439 |
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http://www.nextpeptide.com/ |
| Company Name: |
Bide Pharmatech Ltd.
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400-1647117 13681763483 |
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https://www.bidepharm.com/ |
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