| Identification | Back Directory | [Name]
PEG9-t-butly ester | [CAS]
1334177-84-2 | [Synonyms]
OH-PEG8-TBA
HO-PEG8-COOtBu
Hydroxy-PEG8-Boc
PEG9-t-butly ester
OH-PEG8-CH2CH2COOtBu
HO-PEG8-CH2CH2COOTBU
Hydroxy-PEG8-t-butly ester
Hydroxy-PEG8-t-butyl ester
Hydroxy-PEG7-t-butyl ester
Hydroxy-dPEG8-t-butyl ester
t-Butyl 3-Hydroxy(peg8)propionate
tert-Butyl 1-Hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
2-Methyl-2-propanyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
4,7,10,13,16,19,22,25-Octaoxaheptacosanoic acid, 27-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C23H46O11 | [MDL Number]
MFCD11041105 | [MOL File]
1334177-84-2.mol | [Molecular Weight]
498.6 |
| Chemical Properties | Back Directory | [Boiling point ]
549.5±45.0 °C(Predicted) | [density ]
1.083±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C23H46O11/c1-23(2,3)34-22(25)4-6-26-8-10-28-12-14-30-16-18-32-20-21-33-19-17-31-15-13-29-11-9-27-7-5-24/h24H,4-21H2,1-3H3 | [InChIKey]
RBRDLMWBCQQRIQ-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCO |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG8-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | [General Description]
Hydroxy-PEG8-t-butyl ester (also known as Hydroxy-PEG8-Boc, Hydroxy-PEG8-Boc, HO-PEG8-CH2CH2COO-tBu and OH-PEG8-TBA, etc.; CAS 1334177-84-2) is a high-purity, monodisperse PEG cross-linking agent featuring terminal hydroxyl (-OH) groups and tert-butyl-protected carboxyl groups. This compound is widely used in the development of PROTACs and antibody-drug conjugates (ADCs) to enhance water solubility, improve biocompatibility, and facilitate sequential biocoupling. | [IC 50]
PEGs |
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T&W GROUP
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